| 摘要: |
| 儿童时期，呼吸道病毒感染是哮喘急性加重的重要原因，其中鼻病毒占2/3，而鼻病毒导致哮喘急性发作的机制尚不明确。本文从白介素-17与中性粒细胞炎症反应和气道重塑方面综述白介素-17在鼻病毒感染后哮喘中的作用机制，IL-17可以通过NF-κB，MARP以及T2-ERK1/2-MSK1信号转导通路发挥生物学作用。IL-17A和IL-17RA的单克隆抗体治疗Th17相关炎症的临床研究已有报道，这为治疗鼻病毒感染后哮喘提供了新的思路。 |
| 关键词: 鼻病毒 哮喘 儿童 白介素-17 |
| DOI：10.11724/jdmu.2018.05.16 |
| 分类号:R725.6 |
| 基金项目:基金项目：辽宁省科技厅科学技术计划项目(2013225002) |
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| Mechanism of IL-17 in asthmatic attacks after rhinovirus infection |
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JI Hong1, WU Taihua2
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1.Pediatric Department, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China;2.Respiratory Department, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
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| Abstract: |
| In childhood, respiratory virus infection is an important cause of asthma. Rhinovirus accounted for about 2/3. The mechanism of wheezing caused by rhinovirus is still unclear. This article reviewed the role of IL-17 in asthmatic attacks after rhinovirus infection in airway inflammation and in airway remodeling. We also summarized the clinical trials of IL-17A and IL-17RA monoclonal antibodies in the treatment of IL17-related inflammation in order to provide new ideas for the treatment of asthmatic attcks after rhinovirus infection. |
| Key words: rhinovirus asthma children IL-17 |
