肝性脑病的治疗进展

Advances in the treatment of hepatic encephalopathy

关键词:  肝性脑病  发病机制  药物治疗  介入治疗

Key words:  hepatic encephalopathy  pathogenesis  medical therapy  interventional therapy

摘要:

肝性脑病（hepatic encephalopathy, HE）是严重肝功能失调或障碍导致的中枢神经系统失调的病症。HE主要是肝脏功能衰竭所致，随着肝功能的恶化呈加重趋势。目前临床上HE多以药物治疗为主。随着研究的深入，在传统的药物治疗方法基础之上，手术介入治疗、肝支持系统和营养治疗等多方面都有了新的发现和进展；多项动物试验的研究结果也可以为临床研究提供依据，如以线粒体为靶点来治疗HE已经成为了一种新的研究方向。本文就HE的治疗进展进行综述。

Abstract:

Hepatic encephalopathy (HE) is a serious disorder with magnificence of the central nervous system disorder caused mainly by liver failure. is aggravated with the deterioration of liver function. At present, HE is mostly treated by drugs. With the deepening of research, new discoveries and advances have been made in surgical interventional therapy, liver support system and nutritional therapy on the basis of traditional drug therapies. The results of many animal studies would provide a basis for clinical treatment, such that the treatment of HE with mitochondria as a target has become a new kind of research direction. This article reviewed the progress of HE treatment.