| 摘要: |
| 动脉粥样硬化(atherosclerosis，AS)是一种以脂质在动脉壁上沉积并逐渐发展成粥样斑块的慢性炎症，而Treg细胞具有抗AS的作用，它通过细胞接触抑制和分泌IL-10、TGF-β等细胞因子来抑制效应T细胞的活化和增殖而发挥抗炎作用，抑制斑块的形成和发展，通过研究那些与Treg细胞增殖相关的因素如IL33/ST2、BM-MSCs、ox-LDL、anti-CD3单抗、Myd-88等，为防治AS指出了一个新的方向。 |
| 关键词: 调节性T淋巴细胞 动脉粥样硬化 细胞因子 |
| DOI：10.11724/jdmu.2015.06.24 |
| 分类号:R392.19 |
| 基金项目: |
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| Anti-atherosclerotic Treg cells |
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ZHANG Ying1, YANG Jun-yuan2, LIU Chang-hong3
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1.Medical Postgraduate of Dalian Medical University, 2014 Grade，Dalian 116044，China;2.Second Clinical College of Dalian Medical University, Seven Year 2011，Dalian 116027，China;3.Department of Thoracic Surgery, the Second Affiliated Hospital of Dalian Medical University，Dalian 116027，China
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| Abstract: |
| Atherosclerosis is a process of lipid deposition in the arterial wall with gradual plaque formation in association with chronic inflammation. Treg cells play a protective role in atherosclerosis. Through cell-to-cell contact inhibition and secretion of IL-10, TGF-β and other cytokines, it suppresses effector T cell activation, proliferation and inhibits the formation and development of plaque. Therefore, studying the factors associated with Treg cell proliferation, such as IL33 / ST2, BM-MSCs, ox-LDL, anti-CD3 monoclonal antibody, Myd-88, etc. will provide a new direction for the prevention and treatment of AS. |
| Key words: Treg cells atherosclerosis cytokines |
