三阴性乳腺癌中CK5/6和PTEN的表达及其临床病理意义

Clinical significance of CK5/6 and PTEN expression in human triple-negative breast cancer

关键词:  三阴性乳腺癌  CK5/6  PTEN  预后

Key words:  triple-negative breast cancer  CK5/6  PTEN  prognosis

摘要:

目的　探讨三阴性乳腺癌组织中CK5/6和PTEN的表达及其临床病理意义。　方法　通过免疫组化方法检测68例三阴性乳腺癌组织和22例正常乳腺组织CK5/6和PTEN的表达，分析两者的表达水平与临床病理特征及预后的关系。　结果　CK5/6在三阴性乳腺癌组织阳性率为52.9%（36/68），明显高于正常乳腺组织9.1%（2/22）（P<0.05）。PTEN在三阴性乳腺癌组织阳性率为55.9%（38/68），明显低于正常乳腺组织90.9%（20/22）（P<0.05）。CK5/6和PTEN表达在肿瘤直径<5 cm和≥5 cm间，淋巴结转移数目<5个和≥5个间及是否远处转移间比较，差异均有显著性意义（P<0.05）。三阴性乳腺癌CK5/6阳性组及PTEN阴性组患者的生存时间显著短于CK5/6阴性组及PTEN阳性组（P<0.05）。　结论　三阴性乳腺癌CK5/6表达和PTEN表达缺失与肿瘤大小、淋巴结转移数目及远处转移有关，CK5/6表达和PTEN表达缺失提示患者预后不良。

Abstract:

Objective To investigate the expression of CK5/6 and PTEN in human triple-negative breast cancer and its clinical significance. Methods The expressions of CK5/6 and PTEN in 68 cases of triple-negative breast cancer (TNBC) and 22 cases of normal breast tissue were detected by immunohistochemistry. Results The positive frequency of CK5/6 (52.9%, 36/68) was significantly higher in TNBC than that (9.1%, 2/22) in normal breast tissue (P<0.05). The positive frequency of PTEN (55.9%, 38/68) was significantly lower in TNBC than that (90.9%, 20/22) in normal breast tissue (P<0.05). In tumor size, number of metastatic lymph nodes and distant metastasis, TNBC with CK5/6 positive and PTEN-loss have significantly worse performance (P<0.05). The overall survival was significantly shorter in TNBC cases with CK5/6 positive and PTEN-loss. Conclusion TNBC with CK5/6 positive and PTEN-loss could be related with lymph node metastasis and distant metastasis and the worse prognosis.