妊娠期、哺乳期大鼠正畸牙移动过程中骨密度和骨钙素的变化

Changes in bone mineral density and osteocalcin during orthodontic tooth movement in pregnant and lactation rats

关键词:  妊娠期大鼠  哺乳期大鼠  正畸牙移动  骨密度  骨钙素

Key words:  [Key words]　pregnant rats  lactation rats  orthodontic tooth movement  BMD  osteocalcin

摘要:

[摘要]　目的　探讨妊娠期和哺乳期大鼠正畸牙移动骨改建过程中骨密度和血清骨钙素变化，为临床治疗提供理论依据。　方法　将75只成年雌性Wistar大鼠随机分成妊娠组、哺乳组、正畸加力未妊娠组、正畸加力妊娠组和正畸加力哺乳组，每组15只，并建立妊娠、哺乳大鼠模型。施加近中向正畸力于5组大鼠的右侧上颌第一磨牙，分别在加力7 d，14 d，21 d后取胫骨近端检测骨密度，取静脉血检测骨钙素。　结果　正畸加力妊娠组和正畸加力哺乳组大鼠第7天，14天，21天胫骨近端骨密度均低于正畸加力未妊娠组，差异有显著性意义（P＜0.05）。正畸加力妊娠组第7天，14天，21天胫骨近端骨密度分别与妊娠组比较，差异无显著性意义（P＞0.05）。正畸加力哺乳组第7天，14天，21天胫骨近端骨密度分别与哺乳组比较，差异无显著性意义（P＞0.05）。正畸加力妊娠组和正畸加力哺乳组大鼠第7天，14天，21天血清骨钙素均高于正畸加力未妊娠组，差异有显著性意义（P＜0.05）。正畸加力妊娠组第7天，14天，21天血清骨钙素分别与妊娠组比较，差异无显著性意义（P＞0.05）。正畸加力哺乳组第14天血清骨钙素高于哺乳组，差异有显著性意义（P＜0.05）。　结论　相比于未妊娠大鼠，妊娠期大鼠和哺乳期大鼠正畸牙移动过程中胫骨骨密度降低，血清骨钙素升高。

Abstract:

[Abstract] Objective　To investigate bone mineral density and serum osteocalcin changes during orthodontic tooth movement in pregnant and lactation rats.　Methods　Seventy-five female rats were randomly divided into five groups of fifteen each:pregnant group,lactation group,orthodontic non-pregnant group,orthodontic pregnant group and orthodontic lactation group. To build the pregnant and lactation rats model,and exert medial force on the right side of the maxillary first molar .Each group was divided in 7 days,14 days and 21 days,while the same period of tibial bone mineral density(BMD) and serum osteocalcin (BGP)were detected.　Results　The BMD of orthodontic pregnant group and orthodontic lactation group was both lower than orthodontic non-pregnant group in 7 days，14 days and 21 days(P<0.05).The BGP of orthodontic pregnant group and orthodontic lactation group was both higher than orthodontic non-pregnant group in 7 days，14 days and 21 days(P<0.05).All the difference was statistically significant.　Conclusion　The BMD decreased and BGP increased in pregnant and lactation rats during orthodontic tooth movement as compared with non-pregnant rats.