急性冠脉综合征患者氯吡格雷抵抗的研究进展

Progress of research on clopidogrel resistance in the patients with acute coronary syndrome

关键词:  急性冠脉综合征  血小板  氯吡格雷  抵抗

Key words:  [Key words] acute coronary syndrome(ACS)  platelet  clopidogrel  resistance

摘要:

[摘要]　氯吡格雷是一种临床常见的抗血小板药物，在急性冠脉综合征患者中应用广泛。长期随访发现，部分患者对氯吡格雷无反应或低反应，即存在药物抵抗现象。氯吡格雷低抗者的血小板聚集率高、不良心血管事件发生率增加。本文对氯吡格雷的作用机制、氯吡格雷抵抗的检测方法、原因及治疗对策等作一综述。

Abstract:

[Abstract] Clopidogrel plays a significant role in the prevention of thrombotic events in patients with acute coronary syndrome，but a substantial number of patients demonstrate no response or low response to the drug，which is regarded as the phenomenon of drug resistance. Clopidpgrel-resistance patients have higher platelet aggregation and more frequency to suffer from adverse cardiovascular events than the others．The mechanism of the reaction and resistance of clopidogrel, measurement of clopidogrel resistance together with the treatment strategy are compeahended in this article．