宫颈微偏腺癌的诊治进展

Minimal deviation adenocarcinoma of the uterine cervix-Progress of the clinical diagnosis and treatment

关键词:  宫颈  微偏腺癌  恶性腺瘤  诊断

Key words:  [Key words] cervix  minimal deviation adenocarcinoma  adenoma malignum  diagnosis

摘要:

[摘要]　宫颈微偏腺癌(Minimal deviation adenocarcinoma of the uterine cervix,MDA)是一种极为特殊的宫颈腺癌类型，最常见的临床症状为阴道排液，最常见的体征为宫颈肥大。因癌变病灶位置较深，组织学特殊，临床诊断较困难，常规检查易漏诊、误诊，病理组织学检查是最终确诊依据，联合免疫组化检测可提高诊断准确性。明确诊断后应尽早采用根治性手术治疗，术后辅助放、化疗。由于MDA具有浸润深、转移快的恶性生物学行为，而且发病早期诊断困难，对放、化疗不敏感，总体预后较差。

Abstract:

[Abstract] Minimal deviation adenocarcinoma of the uterine cervix (MDA) is a very special type of cervical adenocarcinoma. Vaginal drainage is the most common clinical symptom and cervical hypertrophy is the most common sign. Due to the deep location of the cancerous lesion, special histologic findings, and difficulty in clinical diagnosis, MDA is easily missed and misdiagnosed by regular check-up. Histologic examination provides the final diagnosis with improved diagnostic accuracy by immunohistochemical stains. A radical hysterectomy should be adopted as soon as possible once the diagnosis is established, combined by post-surgical adjuvant chemotherapy and radiation therapy. Nevertheless, the overall prognosis of MDA remains poor due to the malignant biological behavior of the tumor with deep invasion and rapid metastasis, difficulty in early diagnosis, and resistance to chemo-radiation therapy.