HGF和TGF-β1在非小细胞肺癌中的表达及意义

Expression and significance of hepatocyte growth factor and transforming growth factor-β1 in non-small cell lung cancer

关键词:  非小细胞肺癌  肝细胞生长因子  转化生长因子β1

Key words:  [Key words] non-small cell lung cancer  hepatocyte growth factor  transforming growth factor-β1

摘要:

[摘要] 目的　探讨HGF和TGF-β1在非小细胞肺癌(NSCLC)中的表达及临床意义。方法　采用免疫组织化学方法检测73例非小细胞肺癌患者癌组织中及30例癌旁正常肺组织中HGF及TGF-β1的表达；分析HGF及TGF-β1表达情况及与临床病理参数之间的关系。结果　73例肺癌组织中HGF的阳性表达率为67.1%，在30例癌旁正常组织的阳性表达率为16.7%，两者差异有显著性意义(P<0.05)；HGF的表达与肺癌淋巴结转移密切相关(P<0.05)，而与病理组织类型及肿瘤的分化程度无显著相关(P均>0.05)。73例肺癌组织中TGF-β1的阳性表达率为49.3%,在30例癌旁正常肺组织的阳性表达率为16.7%,两者比较差异也有显著性意义(P<0.05)；TGF-β1的表达与肿瘤的分化程度、淋巴结转移密切相关(P均<0.05),而与病理组织类型无显著相关(P>0.05)。经Spearman相关分析, HGF与TGF-β1在NSCLC组织中的表达呈显著正相关(r=0.340,P<0.05)。结论　在NSCLC中存在HGF与TGF-β1的高表达,两者的高表达可能促进了肿瘤的恶性增殖及淋巴结转移；联合检测HGF及TGF-β1对判断NSCLC恶性程度、转移潜能及预后有重要临床意义。

Abstract:

[Abstract] Objective To investigate the expression and clinicopathologic significance of hepatocyte growth factor (HGF) and transforming growth factor-β1 (TGF-β1) in non-small cell lung cancer (NSCLC). Methods Applying the immunohistochemical technique, the expression of HGF and TGF-β1 in 73 patients with non-small cell lung cancer and 30 peri-cancerous normal lung tissue samples were determined. Relationships of expression of HGF and TGF-β1 with clinicopathologic features were analyzed. Results Of 73 patients with NSCLC, the positive expression rate of HGF was 67.1%, however, in 30 cases of peri-cancerous normal tissues, the positive expression rate of HGF was 16.7%,so expression of HGF in peri-cancerous normal tissues was significantly lower than in NSCLC tissues, there was statistical significance (P<0.05).Expression of HGF was significantly associated with lymphnode metastasis (P<0.05), while expression of HGF had no significant associated with tumor pathological types and degree of cell differentiation (P>0.05). Of 73 patients with lung cancer, the positive expression rate of TGF-β1 was 49.3%, in 30 cases of peri-cancerous normal tissues, the positive expression rate of TGF-β1 was 16.7%, so expression of TGF-β1 in peri-cancerous normal tissues was significantly lower than in NSCLC tissues, there was statistical significance(P<0.05). Expression of TGF-β1 was significantly associated with degree of cell differentiation and lymph node metastasis (P<0.05),while expression of TGF-β1 had no significant associated with tumor pathological types (P>0.05).By the analysis of Spearman correlation, the expression of HGF was strongly positive correlated to TGF-β1 expression in lung cancer tissues (r=0.340,P<0.05). Conclusion Overexpression of HGF and TGF-β1 exists in lung cancer, expression of HGF and TGF-β1 were both associated with lymph node metastasis；this suggests that overexpression of HGF and TGF-β1 has important significance in analyzing the degree of malignancy，the otential capacity of metastasis and prognosis．