β-tubulinⅢ在进展期胃癌组织中的表达及临床意义

Expression and clinical significance of β-tubulinⅢ in advanced gastric cancer tissue

关键词:  胃癌  β-tubulinⅢ  紫杉烷类  预后

Key words:  [Key words] gastric cancer  β-tubulinⅢ  taxanes  prognosis

摘要:

[摘要] 目的探讨β-tubulinⅢ在胃癌组织中的表达，与肿瘤临床特征的关系及其对含紫杉烷类药物辅助化疗患者无病生存期（DFS）和总生存期（OS）的影响。方法　收集34例胃癌根治术后应用含紫杉烷类药物辅助化疗且已经死亡患者的完整资料。应用免疫组织化学方法检测β-tubulinⅢ在术后病理组织中的表达，采用χ 2检验分析β-tubulinⅢ表达与肿瘤临床特征的关系。采用Kaplan-Meier方法分析β-tubulinⅢ表达对含紫杉烷类药物辅助化疗患者生存期的影响。结果　(1) 在34例胃癌患者中，β-tubulinⅢ表达15例，阳性表达率44.1%。β-tubulinⅢ的表达与肿瘤发病部位、大小、浸润深度、组织学类型、淋巴结转移、TNM分期无关。(2)β-tubulinⅢ阳性表达患者DFS 10个月，中位OS 18个月；β-tubulinⅢ阴性表达患者DFS 15个月，中位OS为21个月。β-tubulinⅢ阴性表达与阳性表达患者的DFS及中位OS相比，差异有显著性意义，P<0.05。结论　β-tubulinⅢ在胃癌组织中的表达可能作为胃癌根治术后接受紫杉烷类药物敏感性的预测指标，但与肿瘤临床特征无关。

Abstract:

[Abstract] Objective To explore the correlation between the expression of β-tubulinⅢ in gastric cancer tissues and clinical features of tumor, and to explore the effects of β-tubulinⅢon the disease free survival (DFS) and overall survival(OS) of the patients treated with taxanes as adjuvant chemotherapy. Methods We have collected 34 patients who accepted radical resection of gastric cancer and taxanes as postoperative adjuvant chemotherapy. And all the 34 patients have died. The expression of β-tubulinⅢ was detected by immunohistochemical method.The correlation between the expression of β-tubulin Ⅲ in gastric tissues and clinical features of tumor was analyzed by χ2 test. The correlation between the expression of β-tubulin Ⅲ on the survival of patients with taxanes as adjuvant chemot herapy was analyzed by Kaplan-Meier approach. Results In 34 cases of gastric cancer patients, 15 cases have β-tubulin Ⅲ expression,the positive expression rate is 44.1%。The expression of β-tubulin Ⅲ has no correlation with tumor site,size of tumor,depth of invasion,histological type,lymphatic metastasis and TNM stage. The disease free survival (DFS) of patients with positive expression of β-tubulin Ⅲ was 10 months,and 18 months of overall survival(OS).The disease free survival(DFS) of patients with negative expression of β-tubulin Ⅲ was 15 months,and 21 months of overall survival(OS). Compared positive expression of β-tubulin Ⅲ patients，the negatives have significant difference in DFS and median OS, P<0.05. Conclusion The expression of β-tubulinⅢ in gastric tissues can be used as predictive indicators taxane drug sensitivity,which after gastric cancer radical surgery, but does not correlate to the characteristics of clinical oncology.