p53、C-erbB-2、VEGF-C和nm23在乳腺癌中的表达及临床意义

Expression and clinical significance of p53, C-erbB-2, VEGF-C and nm23 in breast cancer

关键词:  乳腺癌  p53  C-erbB-2  VEGF-C  nm23

Key words:  breast cancer  p53  C-erbB-2  VEGF-C  nm23

摘要:

[目的] 探讨p53、C-erbB-2、VEGF-C和 nm23在乳腺癌中的表达及临床意义。[方法]应用免疫组化SP法检测100例乳腺癌组织及其癌旁正常乳腺组织活性标本中p53、C-erbB-2、VEGF-C和 nm23蛋白表达情况。[结果]乳腺癌组织和癌旁正常组织中p53、C-erbB-2、VEGF-C和 nm23蛋白阳性表达率分别为86.0%和30.0%、76.7%和25.0%、80.0%和20.0%， 30.0%和90.0%；p53和C-erbB-2蛋白阳性表达在有无淋巴结转移、不同临床分期和癌分化程度上差异有显著性意义（P<0.05）；VEGF-C蛋白阳性表达在有无淋巴结转移、肿瘤大小和癌分化程度上差异有显著性意义（P<0.05）；nm23蛋白阳性表达在有无淋巴结转移上差异有显著性意义（P<0.05）。[结论]p53、C-erbB-2和VEGF-C阳性表达是乳腺癌患者预后差的指标，nm23表达则提示乳腺癌患者预后较好，联合检测p53、C-erbB-2、VEGF-C和nm23有助于乳腺癌患者的治疗和预后判断。

Abstract:

［Objective］ To study the expression and clinical significance of p53, C-erbB-2, VEGF-C and nm23 in breast cancer. ［Methods］ The expression of p53, C-erbB-2, VEGF-C and nm23 were examined in 100 cases of breast cancer and adjacent normal breast tissue without chemotherapy by using SP immunohistochemical technique. ［Results］ In 100 cases of breast cancer and adjacent normal breast tissue, the positive rate of p53, C-erbB-2, VEGF-C and nm23 were 86.0% and 30.0%, 76.7% and 25.0%, 80.0% and 20.0%, 30.0% and 90.0%, respectively. There were significant difference in the positive rates of p53 and C-erbB-2 in different lymphatic metastasis, clinical stages and histological grade (P<0.05); The expression of VEGF-C was significantly related with lymphatic metastasis, tumor sizes and histological grade (P<0.05); It showed significant correlations of the positive rate of nm23 in lymphatic metastasis (P<0.05). [Conclusion]　The expression of p53, C-erbB-2, VEGF-C and nm23 were positively related to the metastasis and prognosis of breast cancer, the combined detection of p53, C-erbB-2, VEGF-C and nm23 is valuable to predicting prognosis and guiding therapy of breast cancer.