口腔扁平苔藓中MMP-2和MMP-9的表达及意义

Expression and significance of oral lichen planus in MMP-2 and MMP-9

关键词:  基质金属蛋白酶2  基质金属蛋白酶9  扁平苔藓  口腔

Key words:  matrix metalloproteinase-2  matrix metalloproteinase-9  lichen planus  oral

摘要:

[目的] 探索MMP-2和MMP-9与口腔扁平苔藓（oral lichen planus,OLP）的发生、发展乃至癌变潜能的关系。[方法]采用免疫组化SP法检测MMP-2和MMP-9在22例OLP、11例正常口腔黏膜组织、22例白斑和22例口腔鳞癌组织表达。[结果]在正常口腔黏膜、扁平苔藓、白斑和鳞癌组织中MMP-2和MMP-9的表达依次增加。MMP-2和MMP-9在口腔扁平苔藓和白斑中的表达显著高于正常口腔黏膜 (P<0.05)，但在口腔扁平苔藓和白斑间的表达差异无显著性意义(P>0.05)；在鳞癌中的表达显著高于其他3组 (P<0.05)。[结论]MMP-2和MMP-9表达与OLP的发生、发展乃至癌变潜能有关。

Abstract:

[Objective] To Explore the relationshiops of MMP-2 and MMP-9 to the OLP occurrence, the development and even the canceration potential. [Methods] Immunohisto- chemistry was performed to examine expressions of MMP-2 and MMP-9 in 22 OLP, 11 normal oral mucosa, 22 oral leukoplakia and 22 squamous cell carcinoma. [Results] The expression of MMP-2 and MMP-9 increased in turn from normal oral mucosa to OLP, oral leukoplakia and oral squamous cell carcinoma tissues. The expression of MMP-2 and MMP-9 in OLP and oral leukoplakia was significantly higher than that in normal oral mucosa (P<0.05), there was significant difference; There was no significant difference between the positive expression of MMP-2 and MMP-9 in OLP and oral leukoplakia (P>0.05); The expression of MMP-2 and MMP-9 in squamous cell carcinoma was significantly higher than The other three groups (P<0.05)，there was significant difference. [Conclusion] The expression levels of MMP-2 and MMP-9 correlate with the occurrence of oral lichen planus, development and even cancer potential, which may be useful indicator to judge the possibility of malignant change of OLP.