| 摘要: |
| ［目的］研究磷霉素与其它9种临床常用抗菌药物分别联合应用对47株不动杆菌的体外抗菌活性。［方法］收集痰标本中分离出的不动杆菌47株，将磷霉素与其它9种抗菌药物在体外单独以及联合应用，采用琼脂二倍稀释法，测定最低抑菌浓度（MIC）、计算部分抑菌浓度（FIC）指数，评价磷霉素与其它9种抗菌药物分别联合应用的体外抗菌活性。［结果］磷霉素、左氧氟沙星、环丙沙星、头孢呋辛、头孢他啶、头孢吡肟、头孢哌酮/舒巴坦、阿米卡星单独应用时对47株不动杆菌的MIC50值均显示耐药，磷霉素分别与这9种抗菌药物在体外按1∶1联合应用后，MIC值均比单独应用时有所下降，FIC指数均≤2，协同及相加作用的比例大于无关作用的比例，未见拮抗作用，磷霉素与阿米卡星联用后，使后者由耐药变成敏感。［结论］磷霉素与左氧氟沙星、环丙沙星、头孢呋辛、头孢他啶、头孢吡肟、头孢哌酮/舒巴坦、美罗培南、亚胺培南/西司他丁、阿米卡星在体外分别联合应用对不动杆菌有协同及相加作用，增强了这9种抗菌药物的抗菌活性。 |
| 关键词: 磷霉素 不动杆菌 联合用药 体外抗菌活性 相互作用 |
| DOI：10.11724/jdmu.2011.03.26 |
| 分类号:R965.2 |
| 基金项目: |
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| In vitro antibacterial activity of fosfomycin combined with nine antimicrobial agents against acinetobacter |
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YANG Ying-ying1,2, WANG Zhen-shan1, XUE Xin1, NIE Da-ping3, LI Yu-zhong3
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1.Department of Respiration,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China;2.Department of Internal Medicine,Fengcheng Central Hospital,Dandong 118100,China;3.Department of Clinical Laboratory,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China
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| Abstract: |
| ［Objective］To study the antibacterial activity of fosfomycin combined with other 9 antimicrobial agents against 47 strains of Acinetobacter in vitro, in order to provide laboratory data for clinical combination application.［Methods］The 47 strains of acinetobacter isolated from sputum samples were treated by 10 antimicrobial agents alone and by fosfomycin combined with other 9 antimicrobial agents.Through the minimal inhibitory concentration (MIC) and fractional inhibitory concentration (FIC) index, using a two-fold agar dilution method, we could evaluate the antibacterial activity of fosfomycin combined with other 9 antimicrobial agents in vitro.［Results］All the 47 strains of acinetobacter were resistant to fosfomycin, levofloxacin, ciprofloxacin, cefuroxime, ceftazidime, cefepime, cefoperazone/ sulbactam, amikacin, and were intermedium to meropenem and imipenem/cilastatin.The ratio of antimicrobial agents was 1:1.The MICs of fosfomycin combined with other 9 antimicrobial agents were lower than those of 10 antimicrobial agents alone and FIC index≤2.The primary action was synergistic/additional effect.There was no antagonistic effect observed.［Conclusion］Synergistic/additional effect was observed in fosfomycin combined with levofloxacin, ciprofloxacin, cefuroxime, ceftazidime, cefepime, cefoperazone/sulbactam, amikacin, meropenem and imipenem/cilastatin against acinetobacter in vitro.The antimicrobial activities of combination were increased. |
| Key words: fosfomycin acinetobacter antibiotics combination in vitro antibacterial activity interaction |
