体检人群高尿酸血症患病情况及血尿酸与血肌酐水平检测分析

Prevalence of hyperuricemia and the analysis of blood uric acid and creatinine in 5883 inhabitants

关键词:  血尿酸  血肌酐  高尿酸血症  患病率

Key words:  serum uric acid  creatinine  hyperuricemia  prevalence

摘要:

［目的］了解大连地区健康人群血尿酸、血肌酐水平及高尿酸血症患病率情况。［方法］对大连地区5883例健康体检者血尿酸含量及血肌酐水平进行检测并进行统计学分析。［结果］（1）本组高尿酸血症患病率平均为14.7%。男性21.3%，女性4.6%。男性患病率明显高于女性，差异有显著性意义（P<0.001）。（2）男性＜50岁各年龄组高尿酸血症患病率21.9%～27.0%，其中＜30岁组最高，为27.0%；≥50岁各年龄组患病率有所下降，为18.0%～21.4%，其中≥70岁组患病率最高，为21.4%。（3）女性＜50岁各年龄组患病率为4.7%～5.8%；≥50岁各年龄组患病率有所上升，为1.2%～6.3%，以≥70岁年龄组患病率最高，为6.3%。（4）男性女性血肌酐水平在＜70岁各年龄组间差异无显著性意义（P＞0.05），≥70岁组血肌酐水平较70岁以前各年龄组明显升高，差异具有显著性意义（P<0.05）。［结论］（1）大连地区健康人群高尿酸血症患病率较高，男性明显高于女性，且呈现年轻化趋势。（2）≥70岁人群，无论男性、女性，血肌酐水平较＜70岁组人群均明显增高，血尿酸水平随之增高。

Abstract:

［Objective］To explore the prevalence of hyperuricemia and to investigate the relationship between the blood uric acid and creatinine in 5883 inhabitants in Dalian area. ［Methods］Concentrations of blood uric acid and creatinine in 5883 healthy citizens in Dalian area were investigated. ［Results］(1) The prevalence of hyperuricemia was 14.7% in this population, while 21.3% in males and 4.6% in females, which showed that the prevalence of hyperuricemia in males was significantly higher than in females (P<0.001). (2) The prevalence of hyperuricemia was 21.9% to 27.0% in the groups of those who were younger than 50 years old in males, while 18.0% to 21.4% in those who were older than 50 years. (3) The prevalence of hyperuricemia was 4.7% to 5.8% in the groups of those who were younger than 50 years old in females, while 1.2% to 6.3% in those who were older than 50 years. (4) No matter in men or women, there was no significant difference in the level of creatinine before 70 years old. (P>0.05). After 70 years old, the concentration of creatinine was higher, and comparing with the groups of those who were younger than 70 year old, the difference is significant (P<0.05). ［Conclusions］(1) The prevalence of hyperuricemia is high in population of Dalian, and it is higher in males than that in females. Especially, it happens in more and more young people. (2) In people that are younger than 70, the concentrations of creatinine have no significant difference between male and female, while it is higher in both who are older than 70, and the same occurs in blood uric acid.