| 摘要: |
| CXC趋化因子受体2（CXC chemokine receptor 2，CXCR2）属于趋化因子受体的一种，为7次跨膜G蛋白偶联受体，主要表达于中性粒细胞、巨噬细胞、血管内皮细胞和肿瘤细胞等细胞表面。CXCR2与其配体结合后，参与机体的多种病理生理过程，包括炎症、感染、创伤愈合和肿瘤发生等过程，其在恶性肿瘤演进中所起的作用是多方面的，它通过直接促进肿瘤生长、转移以及通过促进肿瘤血管形成、白细胞浸润，共同促进了肿瘤的发生发展。近年来，CXCR2在肿瘤血管生成中的作用日益受到重视。CXCR2在不久的将来有望成为抗肿瘤的一个新的靶点。 |
| 关键词: CXC趋化因子受体2 白介素8 血管形成 肿瘤 |
| DOI：10.11724/jdmu.2010.05.29 |
| 分类号: |
| 基金项目: |
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| CXC chemokine receptor 2 and tumor angiogenesis |
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FENG Jing-fei1, LI Fang2
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1.Seven-year Program of Clinical Medicine,Dalian Medical University,Dalian 116044,China;2.Department of Immunology,Dalian Medical University,Dalian 116044,China
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| Abstract: |
| CXC chemokine receptor 2 is a member of the chemokine receptors,which possesses seven hydrophobic transmembrane domains and expresses on the surface of neutrophils,macrophages,endothelial cells,tumor cells,etc.When CXCR2 binds with its ligands,it will play a role in many patho-physiological conditions,including inflammation,infection,wound healing,and tumorigenesis.The role of CXCR2 in malignant tumors is complex:CXCR2 may participate in tumor growth and metastasis by promoting tumor cell proliferation,migration,
angiogenesis or neutrophil infiltration in tumor tissue.In recent years,with the development of tumor-related studies,CXCR2 in the role of tumor angiogenesis have received increasing attention,CXCR2 in the near future may become a new anti-cancer target. |
| Key words: CXCR2 interleukin-8 angiogenesis tumor |
