| 引用本文: | 田 燕,高 萌,蒋 妮,傅昌龙,周欢欢,明从坤,田 舸.齐墩果酸滴丸的制备及质量评价[J].大连医科大学学报,2010,32(5):521-523+538. |
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| 摘要: |
| ［目的］制备齐墩果酸滴丸并测定其溶出度。［方法］按常规方法制备滴丸，采用RP-HPLC法，色谱柱为HYPERSIL C18柱，用甲醇∶0.03%醋酸水溶液（90∶10）为流动相，检测波长为210 nm处测定自制齐墩果酸滴丸的含量和溶出度。［结果］制得的滴丸大小均匀、圆整光滑、硬度适中。齐墩果酸的检测浓度在10～160 μg/mL范围内与吸光度呈良好线性关系（r=0.9992），含药量为5.09%（RSD=2.17%）。齐墩果酸滴丸30 min时溶出度为（85.2±1.04）%。［结论］该制备方法简单，滴丸成形性好，质量可控，体外溶出度高。 |
| 关键词: 齐墩果酸 滴丸 RP-HPLC法 质量 |
| DOI：10.11724/jdmu.2010.05.07 |
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| Preparation and quality evaluation of oleanolic acid drop pills |
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TIAN Yan1, GAO Meng1, JIANG Ni2, FU Chang-long3, ZHOU Huan-huan3, MING Cong-kun3, TIAN Ge1
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1.Pharmaceutical College, Dalian Medical University, Dalian 116044, China;2.Department of Pharmaceutics, Dalian Children Hospital, Dalian 116001, China;3.Dalian Medical University Students at Grade 2008 in Medical Seven Grade, Dalian 116044, China
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| Abstract: |
| ［Objective］To prepare oleanolic acid (OA) drop pills and evaluate their quality.［Methods］The drop pills were prepared by a routine method.The content of OA and the dissolution rates of OA drop pills were determined by RP-HPLC on HYPERSIL C18 column (4.6 mm×250 mm, 5 μm) with methanol-0.03% HOAc solution (90:10) as the mobile phase, and the detective wavelength was 210 nm.［Results］The drop pills were well-distributed in size, smooth and glossy in appearance, mild in hardness.The line arrange for OA was 10～160 μg/mL(r=0.9992), with the content was 5.09% (RSD=1.27%).The dissolution rate of OA drop pills was(85.2±1.04)% at 30 minutes.［Conclusion］The prepared method of OA drop pills is simple, and the drop pills are well-shaped with controllable quality and high dissolution rate. |
| Key words: oleanolic acid drop pills RP-HPLC quality |
