多发性硬化患者血清IL-17水平和髓鞘碱性蛋白相关性的研究

A correlative study of IL-17 and MBP in serum of patients with multiple sclerosis

关键词:  多发性硬化  IL-17  髓鞘碱性蛋白

Key words:  multiple sclerosis  IL-17  myelin basic protein

摘要:

［目的］检测多发性硬化（multiple s clerosis，MS）患者血清IL-17水平，分析其与髓鞘碱性蛋白（myelin basic protein，MBP）的关系。［方法］收集18例急性发作期、17例缓解期MS患者和39例正常人对照组血清，采用ELISA方法检测血清IL-17和MBP水平。［结果］急性发作期MS患者血清IL-17和MBP分别为（109.4±34.2）pg/ mL和（12.9±4.8）ng/mL，均高于缓解期MS患者的（68.5 ±17.6）pg/mL和（6.1±2.5）ng/mL，与正常对照组（56.4±10.7）pg/mL和（3.6±1.5）ng/mL比较，差异具有显著性意义（P均<0.05）。MS患者血清IL-17水平与MBP关系呈正相关关系（P<0.05）。［结论］MS患者血清IL-17和MBP的水平均升高，与疾病活动有关。

Abstract:

［Objective］To detect the level of serum IL-17 and analyze the relationship between IL-17 and myelin basic protein (MBP) in patients with multiple sclerosis (MS).［Methods］IL-17 and MBP were detected by ELISA from 18 acute MS patients,17 remitting MS patients and normal controls.The correlation between IL-17 and MBP was analyzed.［Results］The serum level of IL-17 and MBP in acute MS patients were (109.4±34.2) pg/mL and (12.9±4.8) ng/mL,and significantly higher than that of remitting MS (68.5±17.6) pg/mL,(6.1±2.5) ng/mL(P<0.05),and normal control (56.4±10.7) pg/mL,(3.6±1.5) ng/mL(P<0.05).There was positive correlation between IL-17 and MBP.［Conclusion］High expressions of IL-17 and MBP were shown in MS,and related with disease activity.