认知激活下轻度抑郁者脑血流变化的研究

Study of cognition activated regional cerebral blood flow diversity in mild depression

关键词:  抑郁  认知激活  发射型计算机  单光子  局部血流

Key words:  depression  cognition  tomography  emission computed  single photon  regional blood flow

摘要:

［目的］ 利用SPECT半定量分析，探讨未经治疗的轻度抑郁者在认知激活条件下脑血流的变化。［方法］ 轻度抑郁组和正常对照组各12例，隔日行基础状态及认知激活下SPECT脑血流灌注显像，在重建横断面图像各层面上勾画额叶、颞叶、顶叶、丘脑、基底节、枕叶及小脑感兴趣区（ROI），计算相应脑区平均计数。对各脑区rCBF与小脑rCBF平均计数的比值进行分析，比较不同状态下两组被试各脑区rCBF的差别。［结果］对照组认知激活相对于基础状态，右侧额叶（0.996±0.094 vs 0.942±0.047）及左侧基底节区（1.094±0.103 vs 1.038±0.049）脑血流差异有显著性意义（P<0.05）。轻度抑郁组认知激活及基础状态下各脑区rCBF差异无显著性意义（P>0.05）。［结论］认知激活实验有助于发现抑郁者脑血流的变化，对于疾病的生物学研究及早期诊断可能会有帮助。

Abstract:

［Objective］ To investigate cognition activated regional cerebral blood flow (rCBF) diversity in mild depression patients using SPECT semiquantitative analysis. ［Methods］ SPECT imaging was performed on 12 mild depression patients and 12 matched healthy volunteers. All subjects performed cognitive task in the first day and basic task in the third day. Variation of rCBF in depression and control group was analyzed with ROIs method under the conditions of basic and cognitive task. ［Results］ Compared with the basic state, rCBF of healthy volunteers was significantly increased in right frontal lobe (0.996±0.094 vs 0.942±0.047) and left basal ganglia (1.094±0.103 vs 1.038±0.049) after cognition activation. P value was set at 0.05 level. There wasn’t significant difference between cognition and basic state in mild depression group.［Conclusions］ We can find light diversity of rCBF in depression through the cognition activated test, which could make for biological study and early diagnosis to depression.