IL-1β+3953基因多态性与2型糖尿病伴发牙周病关系的研究

Association between interleukin-1 genetic polymorphism,diabetes and periodontitis

关键词:  2型糖尿病  牙周炎  白介素1

Key words:  periodontal disease  diabetes mellitus  interleukin-1

摘要:

［目的］ 分析IL-1β+3953 等位基因与2型糖尿病伴发牙周病的相关关系，为预防糖尿病伴发牙周病的发生和干预性治疗提供理论依据。［方法］ 用PCR—RFLP方法分别检测对照组、单纯2型糖尿病组、单纯牙周病组、2型糖尿病伴发牙周病组，IL-1β+3953基因多态性。［结果］ IL-1β+3953等位基因2型在糖尿病伴牙周炎患者中的携带率（14.29%）明显高于单纯的糖尿病组（8.7%）（P<0.05）或单纯牙周炎患者组（11.54%）（P<0.05）及健康对照组（0%）（P<0.05）。［结论］ IL-1β+3953等位基因2型的存在与牙周炎及糖尿病的发生具有统计学意义，在糖尿病患者中具有IL-1β+3953等位基因II的人群伴发牙周炎的概率明显增高。

Abstract:

［Objective］ The aim of this study is to evaluate the relationship between type II diabetes, the IL-1β(+3953) genetic polymorphisms,and periodontitis in a population-based study. ［Methods］ Blood samples were collected and analyzed for genotyping of IL-1B (+3953) polymorphisms. ［Results］ For allele frequency analysis, the frequency of allele I/II was significantly higher in the chronic diabetic and periodontitis group than periodontitis or diabetic group (P<0.05). There was a gene-environmental interaction because diabetic subjects bearing a variant IL-1 genotype I/II had an enhanced risk for periodontal disease in comparison with their IL-1 wild-type counterparts. ［Conclusions］ These data confirm that there is a trend suggesting that allele I/II at IL-1β(+3954) is over-represented among diabetics with periodontal disease. Subjects with type II diabetes have an increased risk for periodontitis, which is aggravated further if combined with the variant IL-1A/1B genotype.