| 摘要: |
| GluR2亚基由于其mRNA Q/R位点编辑，使得它在AMPA受体中的相对含量决定了AMPA受体的钙离子不通透性。在多种神经性损伤或退行性疾病中，神经元GluR2表达下调，Ca2+ 内流增加。但是目前关于GluR2下调机制，GluR2在神经元死亡或耐受中的作用及机制尚未完全阐明。本文就AMPA受体GluR2亚基调控及其与神经元损伤关系的研究进展作一综述。 |
| 关键词: AMPA受体 GluR2 神经元 |
| DOI：10.11724/jdmu.2009.04.28 |
| 分类号:Q189；Q291 |
| 基金项目: |
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| Progress of research on GluR2 subunits of AMPA receptors |
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JIA Yu-hong1, MA Tian-shu2, JIANG Miao-na1
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1.Department of Pathophysiology, Dalian Medical University, Dalian 116044, China;2.Dalain Institute of Traditional Chinese Medicine, Dalian 116013, China
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| Abstract: |
| The relative presence of GluR2 subunits in AMPA receptors (AMPARs) determines the Calcium-impermeability of AMPARs because of GluR2 mRNA Q/R edit. In a wide range of neurological insults and neurodegenerative disorders neuronal expression of GluR2 reduced and Ca2+ influx into neurons increased. But the mechanisms of GluR2 downregulation and the effects of GluR2 on neuronal death and tolerance have still not been completely delineated. This paper reviewed the progress of researches in the regulation of GluR2 subunits of AMPARs and the relationship of GluR2 with neuronal damage. |
| Key words: AMPA receptor GluR2 neuron |
