CK-MB质量、CK-MB活性在急性心梗及脑外伤性疾病中的应用探讨

Evaluation of application of CK-MB quality and activation in acute myocardial infarction and extracranial disease

关键词:  急性心肌梗死  肌酸激酶同工酶质量  肌酸激酶同工酶活性  脑外伤性疾病

Key words:  AMI  CK-MB mass  CK-MB activity  extracranial disease

摘要:

［目的］ 探讨肌酸激酶同工酶（CK-MB）的质量、肌酸激酶同工酶的活性在急性心梗和脑外伤性疾病中的诊断价值。［方法］ 对30例确诊为急性心肌梗死患者、30例脑外伤性疾病患者、30例健康人进行CK-MB活性、CK-MB质量检测。［结果］ (1)急性心肌梗死组CK-MB活性（55.46±21.95）、CK-MB质量（29.83±17.79）明显高于正常对照组（P<0.01）。但是CK-MB质量升高倍数明显高于CK-MB活性。(2)脑外伤性疾病组CK-MB质量的均值（1.73±0.96）在正常范围内，与对照组比较差异无统计学意义（P>0.01），而CK-MB活性（31.73±20.17）高于正常对照组，差异有统计学意义（P<0.01）。［结论］ CK-MB活性、CK-MB质量在急性心梗诊断中都很敏感，但CK-MB质量对因素干扰稳定性好于CK-MB活性。在脑外伤性疾病组，测定CK-MB质量要好于CK-MB活性，更能反映脑外伤性疾病的真实情况。

Abstract:

［Objective］ To investigate the value of serum CK-MB mass and CK-MB activity levels in the early diagnosis of the patients with acute myocardial infarction (AMI) and extracranial disease. ［Methods］ CK-MB mass, CK-MB activity in serum of 30 cases with AMI, 30 cases with extracranial disease and 30 normal senior subjects were determined. ［Results］ (1) The CK-MB mass(29.83±17.79), CK-MB activity(55.46±21.95) levels in AMI patients were significantly higher than those in normal group (P<0.01). (2) In the extracranial disease group, the concentrations of CK-MB mass(1.73±0.96) was within the referential ranges and if compared to the control group, there was no significant difference (P>0.01). But CK-MB activity(31.73±20.17) was higher than referential ranges with significant difference (P<0.01). ［Conclusion］ There are both well sensitiveity to AMI on CK-MB mass and CK-MB activity while CK-MB mass has better stability than CK-MB activity to different conditions.