| 摘要: |
| 原癌基因Bmi-1属于转录抑制因子Polycomb(PcG)家族，通常作用于INK4a/ARF基因位点而影响细胞增殖及衰老。研究表明，多种成体干细胞和肿瘤干细胞的自我更新及增殖活性的维持也需要Bmi-1基因。Bmi-1基因的表达水平还与肿瘤的侵袭、转移、预后及复发有关，因而有望成为一种新的肿瘤分子标志物。 |
| 关键词: Bmi-1 肿瘤干细胞 肿瘤 |
| DOI：10.11724/jdmu.2009.03.36 |
| 分类号:R392 |
| 基金项目: |
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| Research advancement on relationship between Bmi-1gene and tumor |
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LIU Dan-dan1, ZHANG Yan-li2, MENG Xiu-xiang1,2
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1.Diagnostics Laboratory Center;2.College of Laboratory Medicine , Dalian Medical University, Dalian 116044, China
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| Abstract: |
| Bmi-1, a putative oncogene, belongs to the polycomb group family of transcriptional regulators, which usually affects cell proliferation and insenecence through suppress of the INK4a/ARF locus. It not only supports the proliferation of several adult stem cells and tumor stem cells but also is required for the self-renewal ability of them. Recently researches have indicated that the expression level of Bmi-1 is positively correlated to malignant tumor invasion, distant metastasis, prognosis and recurrence. It has prospective potential to be a valuable tumor molecule marker. |
| Key words: Bmi-1 tumor stem cell tumor |
