| 摘要: |
| ［目的］实验观察溶血现象对丙戊酸钠、卡马西平、苯巴比妥等几种抗癫痫药的血药浓度测定结果的影响。［方法］用注射器针头搅拌血样，建立溶血模型；采用荧光偏振免疫分析法，分别测定溶血前、后血样的血药浓度，结果进行双侧配对 t 检验。［结果］各品种、各浓度的血样溶血前、后的血药浓度，配对 t 检验结果为P>0.05，差异无显著性意义。［结论］溶血现象对丙戊酸钠、卡马西平、苯巴比妥的血药浓度测定没有影响，可按常规方法测定。 |
| 关键词: 溶血 血药浓度 抗癫痫药 抗荧光偏振免疫分析法 |
| DOI：10.11724/jdmu.2008.05.17 |
| 分类号:R971 |
| 基金项目: |
|
| Effect of hemolysis in antiepileptics plasma sample determined by FPIA |
|
LIANG Hui1, TAN Ai-ping1, ZHANG Shao-wei2
|
|
1.Department of Pharamcy,the First Affiliated hospital of Dalian Medical University,Dalian 116011,China;2.Student of Grade 2002 in Clinic Pharmaceutical Specility,Dalian Medical University, Dalian 116044,China
|
| Abstract: |
| ［Objective］To study the effect of hemolysis in antiepileptics plasma sample determined by FPIA.［Methods］The hemolysis model was built by milling blood sample with injector.The antiepileptics concentrations results of determination in normal samples were compared with that in the hemolysis samples.Statistics of the results is paired-sample T test.［Results］There was no significant statistic difference between the determination results of the normal sample and the hemolysis ones( P>0.05 ).［Conclusion］There was no effect of hemolysis in antiepileptics plasma sample determined by FPIA,This kind of samples can be determinated by regular means. |
| Key words: hemolysis drug plasms concentration antiepileptics FPIA |
