缺血修饰白蛋白检测在急性冠脉综合征早期诊断中的应用价值

Value of IMA in early diagnosis of ACS

关键词:  缺血修饰白蛋白（IMA）  急性冠脉综合征（ACS）  肌钙蛋白I（CTNI）

Key words:  aschemia modified albumin  acute myocardial infarction  troponin I

摘要:

［目的］探讨缺血修饰白蛋白（ischemia modified albumin，IMA）检测在急性冠脉综合征（acute coronary syndrome，ACS）早期诊断中的应用价值。［方法］62例确诊ACS患者分别在胸痛发作2、4、6、12、24 h采集静脉血依次检测血中IMA、肌钙蛋白I（CTNI）、肌酸激酶同工酶MB质量（CK-MB mass）水平，另选30例健康体检者做正常对照组，评价IMA对ACS诊断的临床价值。［结果］ACS患者中IMA水平于胸痛发作2 h已经明显升高，4 h仍持续增高，明显高于正常对照组（P＜0.05），6 h开始下降并逐渐回到基线水平.而CTNI、CK-MB mass水平在胸痛发作4~6 h开始升高，24 h达最高。［结论］IMA在ACS早期具有较高的敏感度和特异性，可作为一种较理想的早期诊断ACS的辅助指标。

Abstract:

［Objective］To discuss the value of IMA in early diagnosis of ACS.［Methods］The serum concertrations of IMA、CK-MBmass and CTNI were collected in 62 patients with ACS at 2, 4, 6, 12 and 24 hours after chest pain onset to evaluate role of IMA in the early diagnosis of ACS. Elects another 30 examples with healthy physical examinations as control group.［Results］Serum levels of IMA were obviously elevated and reached peak at 2 hours and even higher at 4 hours after chest pain onset. IMA levels returned to nomal at 6 hours . Serum levels of IMA were obviously higher than the normal control group. Serum levels of CK-MB and CTNI started to elevate at 4~6 hours and obviously at 24 hours after chest pain onset.［Conclusion］IMA has higher sensitivity and specificity in early phase of ACS, and it can be an ideal marker in the early diagnosis of ACS.