盐酸米诺环素软膏辅助治疗慢性牙周炎的疗效研究

Clinical study of periocline on treatment of chronic periodontitis

关键词:  盐酸米诺环素  牙周炎  龈下微生物

Key words:  minocycline hydrochoride  periodontitis  subgingival microbe

摘要:

［目的］评价牙周局部应用盐酸米诺环素软膏（派丽奥）辅助治疗牙周炎的临床疗效。［方法］选取16例慢性牙周炎患者共112颗牙，按奇偶象限将患牙随机分为实验组（盐酸米诺环素软膏治疗组）和对照组（碘甘油治疗组）。记录用药前、用药后第5周和第9周时的牙周临床指标和细菌学指标。［结果］用药后第5周、第9周两组患牙临床指标和细菌学检查均较基线明显改善，实验组牙周临床指标改善优于对照组，差异有显著性意义；龈下附着菌斑中仅螺旋体构成比在两组间差异具有统计学意义。［结论］局部应用盐酸米诺环素软膏（派丽奥）辅助治疗牙周炎，能有效地改善临床症状。

Abstract:

［Objective］To evaluate the clinical effects of periocline as the auxiliary treatment of periodontitis.［Methods］One hundred and twelve teeth with moderate to severe periodontitis( PD≥4 mm) from sixteen patients were selected. The teeth were randomly divided into test group and control group. Periocline(2% minocycline hydrochloride ointment) was applied to the teeth in the test group, while 2% iodine glycerine was applied in the control group. The data including clinical indices and microbiological parameters was collected at the baseline level and on the 5th, 9th week after the therapy.［Results］All the clinical indices and microbiological parameters of both groups were improved obviously, compared with the baseline.The clinical indices of the test group were better than those of control group; and their differences were statistically significant. Only the composition of spirochetes in attached subgingival plaque between the two groups was statistically different.［Conclusion］Local drug delivery of Periocline as the auxiliary treatment of periodontitis, can be effective in improving clinical symptoms.