伊曲康唑治疗ICU侵袭性真菌感染的临床分析

Analisys of efficacy and safety of itraconazloe in treating patients with invasive fugal infection in ICU

关键词:  伊曲康唑  侵袭性真菌感染  ICU

Key words:  itraconazloe  IFI  ICU

摘要:

［目的］评估伊曲康唑治疗ICU中危重患者侵袭性真菌感染（IFI）的疗效及安全性。［方法］回顾性分析37例ICU中诊断IFI的危重患者资料。观察疗效、用药时间与预后、不良反应。［结果］总有效率78.38%（29/37），白色念珠菌感染患者有效率83.33%（20/24），光滑假丝念珠菌感染患者有效率63.64%（7/11），热带念珠菌感染患者有效率50%（2/4）。确诊病例有效率75%（3/4），临床诊断病例有效率80%（24/30），拟诊病例有效率66.67%（2/3）。不良反应发生率37.84%（14/37）。不良反应症状较轻、可逆，对症处置后好转，无需停药。［结论］早期经验性应用伊曲康唑治疗ICU危重患者IFI疗效明确、安全，但应加强监测。

Abstract:

［Objective］To evaluate the efficacy and safety of itraconazloe in treating the invasive fugal infection（IFI）in ICU.［Methods］To reviewed retrospectively the clinical data of 37 patients with the invasive fugal infection in ICU of our hospital . The patients were given itraconazole injection by intravenous infusion, d 1~2 . 200 mg/d, bid; hereafter 200 mg/d; or/and, simultaneously with observation of clinical efficacy, safty, drug administration time and prognosis , adverse reactions.［Results］The total clinical efficacy rate was 78.38%（29/37）.The clinical efficacy rates were 83.33%（20/24）among the patients with the infection of Blastomyces albicans . 63.64%（7/11）among the patients with the infection of Candida glabrata. 50%（2/4）among the patients with the infection of Candida tropicalis . The clinical efficacy rates were the 75%（3/4）among the patients of the definite patients. 80%（24/30）among the probable patients. 66.67%（2/3）among the possible patients.［Conclusion］Itraconazole injection and oral solution show impressive curing activity on IFI in ICU with safety . But must carefully monitor.