| 摘要: |
| ［目的］研究糖尿病肾病（diabetic nephropathy，DN）患者血浆脑利钠肽（BNP）水平及其与糖尿病肾病的关系。［方法］随机选择2型糖尿病患者106例，按尿微量白蛋白排泄率（UAER）分为大量蛋白尿组（UAER>200 μg/min 36例），微量白蛋白尿组（UAER 20~200 μg/min 38例），非白蛋白尿组（UAER<20 μg/min 32例），健康成人30例作为对照组。应用电化学发光法测定各组BNP水平。［结果］微量白蛋白尿组、大量白蛋白尿组血浆BNP水平明显高于非白蛋白尿组（分别为(192.1±72.5) pg/mL、(429.9±165/3) pg/mL、(101.3±46.7) pg/mL，P<0.01），后者高于正常对照组，（57.6±43.4）pg/mL，P<0.01，且与UAER呈明显正相关（r=0.83. P<0.01）。［结论］糖尿病肾病患者血浆BNP水平明显升高，可能在糖尿病肾病发生、发展过程中发挥重要作用。 |
| 关键词: 脑利钠肽 糖尿病肾病 尿蛋白 |
| DOI：10.11724/jdmu.2008.03.25 |
| 分类号:R446 |
| 基金项目: |
|
| Clinical application of plasma BNP detection in diabetic nephropathy patients |
|
WANG Qing, lIU Wei-hong, LENG Feng
|
|
Department of Clinical Laboratory, Dalian Municipal Central Hospital, Dalian 116033,China
|
| Abstract: |
| ［Objective］To investigate the relationship between plasma brain natriuretic peptide level in diabetic patients and diabetic nephropathy, and to evaluate its clinical significance simutanously.［Methods］One hundred and six patients with type 2 diabetic mellitus were enrolled at random. According to urinary albumin execration rate (UAER), 106 patients were divided into three groups: macroalbuminuric group(UAER>200 μg/min),microalbuminuric group (20 μg/min
|
| Key words: brain natriuretic peptide diabetic nephropathy albuminuria |
