| 摘要: |
| ［目的］ 评价肺癌间质血管密度对判定肺癌恶性程度的临床价值。［方法］采用免疫组化方法，对119例肺癌间质血管密度进行检测，并分析其与肺癌病理组织类型、临床分期、淋巴结转移程度的关系。［结果］ 肺癌间质血管密度在各组织类型肺癌差异有统计学意义(P<0.01)，未分化癌具有较强的血管生成能力；I期肺癌中血管密度明显低于Ⅱ期和Ⅲ期肺癌(P<0.01)，发生淋巴结转移组血管密度高于无淋巴结转移组(P<0.01)。［结论］肺癌间质血管密度可作为评价肺癌恶性程度的指标，肺癌间质血管密度高可能促进淋巴结转移发生和肺癌的发展。 |
| 关键词: 肺癌 血管密度 免疫组化 |
| DOI：10.11724/jdmu.2008.03.16 |
| 分类号:R34.2 |
| 基金项目: |
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| Relationship between microvessel density in lung cancer and clinical pathological features |
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SHI En-jin, ZHENG Xin-yu, CHEN Li-ping, LING Guang-lie
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Department of Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, China
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| Abstract: |
| ［Objective］To measure the tumor angiogenesis in primary lung cancer and study the relationship between it and lymph node metastasis.［Methods］Intratumor microvessel density was detected by using ABC immunohistochemistry.［Results］Tumor microvessel density has relationship among all types of lung cancer (P< 0.01). Microvessel density in stageⅠis significantly lower than those in stageⅡand Ⅲ (P< 0.01). Microvessel density is higher in the tumors with lymph node metastasis than not (P< 0.01 ).［Conclusions］Tunor angiogenesis play an important role in the growth and metastasis of lung cancer. |
| Key words: lung cancer microvessel density immunohistochemistry |
