SICAM-1在乙型肝炎患者血清中的表达

Expression of SICAM-1 in serum of hepatitis B patients

关键词:  SICAM-1  乙型肝炎  酶联免疫分析法

Key words:  SICAM-1  hepatitis B  ELISA

摘要:

［目的］ 观察SICAM-1在乙型肝炎患者血清中的表达，探讨SICAM-1与病情的关系。［方法］ 用酶联免疫分析法（ELISA）检测60例乙肝患者和30例健康对照者血清中的SICAM-1水平，同时测定谷丙转氨酶和谷草转氨酶的浓度。［结果］ 转氨酶升高的乙肝患者血清中SICAM-1的水平（201.26±98.69）ng/mL明显高于正常对照组（35.32±10.67）ng/mL（P<0.01）并且高于转氨酶正常乙型肝炎组（36.32±10.67）ng/mL（P<0.01），转氨酶正常乙型肝炎组（36.32±10.67）ng/mL与正常对照组SICAM-1的水平（35.32±10.67）ng/mL差异无显著性意义（P>0.05）。［结论］转氨酶升高的乙肝患者血清中SICAM-1的水平显著升高，表明SICAM-1参与肝炎发病过程，并与发病程度相关，可作为衡量乙型肝炎患者肝损害程度的指标之一。

Abstract:

［Objective］To investigate expression of SICAM-1 in the serum of hepatitis B patients and its relation with diseases.［Methods］SICAM-1 level of 60 hepatitis B patients and 30 healthy control were detected by ELASA , in step detected ALT and AST level.［Results］SICAM-1 in hepatitis B patients whose transaminase increased (201.26 98.69)ng/mL were evidently higher than that in control (35.32±10.67)ng/mL and in hepatitis B patients whose transaminase were normal (36.32±10.67)ng/mL (P<0.01), there was no difference between control groups (35.32±10.67)ng/mL and normal groups 36.32 10.67 ng/mL (P>0.05).［Conclusions］SICAM-1's high level in hepatitis B patients with high transaminase suggests that SICAM takes part in the process of hepatitis episode and it is correlated with degree of the illness . SICAM can act as one of markers evaluating degree of liver injury in hepatitis B patients.