| 摘要: |
| ［目的］探究抗蛋白酶３ (PR3)抗体、抗髓过氧化物酶(MPO)抗体在系统性血管炎患者中检测的临床意义。［方法］ 应用酶联免疫吸附实验(ELISA)检测抗PR3抗体和抗MPO抗体，应用IIF法检测ANCA总抗体。［结果］105例系统性血管炎患者中57例韦格纳肉芽肿患者，主要表现为抗PR3抗体和颗粒型抗中性粒细胞胞质抗体(cANCA)，阳性例数均为41例，阳性率均为71.93%，13例显微镜下多血管炎(MPA)和9例坏死性新月体肾炎(ATH)主要表现为MPO和pANCA, 阳性率分别为53.8%和61.5%,22.22%和33.33%;135例系统性红斑狼疮(SLE)患者，主要表现为抗MPO抗体和核周型抗中性粒细胞胞质抗体(pANCA)，阳性例数分别为29例和32例，阳性率分别是21.5%和23.7%。［结论］抗PR3、抗MPO抗体作为系统性血管炎的一种敏感标记抗体，有利于该疾病的早期诊断及治疗。 |
| 关键词: 抗PR3抗体 抗MPO抗体 系统性血管炎 抗中性粒细胞胞质抗体 |
| DOI：10.11724/jdmu.2007.04.22 |
| 分类号: |
| 基金项目: |
|
| Clinical study of anti-PR and anti-MPO’s detection |
|
MA Rong,WANG Wei-dong,ZHENG Yong-sheng,LI Su-hua
|
|
Department of Clinical Laboratory, the Second Affiliated Hospital of Dalian Medical University, Dlian 116027, China
|
| Abstract: |
| ［Objective］To study the clinical significance of anti-PR3 and anti-MPO's detection in systemic vasculitis.［Methods］Anti-PR3 and Anti-MPO antibodies were detected by ELISA,ANCA Was determined by indirect immunofluorescence(IIF).［Results］We detected antibodies in 105 cases of systemic vasculitis .The positive rate of anti-PR3 antibody and cANCA was 71.93%(41/57)in 57 patients with Wegener's(WG). The positive rate of anti-MPO antibody and pANCA was 53.8% and 61.5% in 13cases of systemic rasculitis under microscope (MPA),then this rate was 22.22% and 33.33% in 9 cases of ATH .The positive rate of anti-MPO antibody and pANCA was 21.5%(29/135) and 27.3%(32/135) in 135 cases of SLE. positive.［Conclusions］PR3 and MPO antibodies are sensitive markers of systemic vasculitis and they are useful for early treatment of the disease. |
| Key words: PR3 antibody MPO antibody systemic vasculitis SLE |
