血浆Hcy水平与冠心病相关性的研究

Study on relation between plasma homocysteine levels and coronary heart disease

关键词:  冠心病  同型半胱氨酸  ELISA

Key words:  coronary heart disease  homocysteine  ELISA.

摘要:

［目的］研究血浆同型半胱氨酸（Hcy）水平与冠心病的关系。［方法］运用ELASA法测定59例冠心病患者和30例正常人血浆总Hcy水平。［结果］ 对照组（n=30）血 浆总Hcy水平为（4.02±5.75）μmol/L;冠心病组共59例,其中心绞痛型冠心病（n=34）血浆总Hcy水平为（24.60±15.99）μmol/L:心肌梗死型冠心病（n=25）血浆总Hcy水平为（30.08±18.11）μmol/L。统计学处理表明对照组与冠心病组之间以及不同冠心病组之间均有显著性差异（P＜0.05）。［结论］冠心病组患者血浆Hcy水平高于正常人；血浆Hcy水平与冠心病的严重程度一致。提示血浆高Hcy水平是冠心病的一个独立危险因素。

Abstract:

［Objective］To investigate the relationship between the plasma homocysteine (Hcy) level and coronary heart disease (CHD).［Methods］Fifty-nine CHD patients and 30 normal subjects were recruited to participate the study.Their plasma total Hcy levels were measured by using ELISA.［Results］For normal controls (n=30), total Hcy level was (4.02±5.75)μmol/L, for patients with angina(n=34), total Hcy level was (24.60±15.99)μmol/L, and (30.08±18.11)μmol/L.For those with myocardial infarction (n=25). Statistically，the mean plasma total Hcy levels between normal and patient group (P<0.05) and among the two patient groups were all significant different (P<0.05).［Conclusions］Plasma Hcy level in CHD patients is higher than that in normal subjects, and the degree of increased level is consistent with the severity of the disease. The results show that high concentration of Hcy in plasma is an independent dangerous factor for coronary heart disease.