血管内皮生长因子－C表达与结肠癌淋巴转移的关系

Study on expression of relationship between vascular endothelial growth factor C expression and lymphatic metastasis in colon cancer organization

关键词:  结肠癌  血管内皮生长因子－C  淋巴转移

Key words:  colon cancer  vascular endothelial growth factor C  lymphatic metastasis

摘要:

［目的］探讨结肠癌组织中血管内皮生长因子－C (VEGF-C)表达与淋巴转移、临床病理参数之间的关系。［方法］将64例结肠癌患者按有无淋巴结转移、性别、年龄、肿瘤大小及TNM分期进行分组，采用免疫组化PV-9000二步法检测其结肠癌组织中VEGF-C 表达情况，应用χ2检验、直线相关分析进行统计学处理。［结果］结肠癌组织中VEGF-C阳性率为57.8％；在淋巴结转移阳性组VEGF-C表达(80%)明显高于淋巴结转移阴性组(38.2%)(P<0.01)。VEGF-C表达与患者性别、年龄、肿瘤大小均无显著相关（r=0.008、0.025、0.013，P>0.05），而与TNM分期显著相关(r=0.447, P<0.01)，其中随着TNM分期的增高，VEGF-C阳性表达亦显著增高。［结论］结肠癌可表达VEGF-C，并影响结肠癌的淋巴转移。VEGF-C高表达而淋巴结转移阴性的病人有很强的淋巴结转移倾向，甚至可能已发生淋巴结微转移。

Abstract:

［Objective］To discuss the relationships between VEGF-C expression, lymphatic metastasis and clinical pathologic characteristics.［Methods］Divide the 64 case of colon cancer tissue into several groups according to lymphatic metastasis, sex, age, tumour size and TNM stages, immunohistochemistry PV-9000 two steps method was performed to measure the situation of VEGF-C expression , apply chi-square test and linear correlation to do statistics processing.［Results］The percentage of positive VEGF-C is 57.8% in colon cancer organization; In lymphatic metastasis positive group VEGF-C positive expression with (80%) is significantly higher than that of lymphatic metastasis negative group (38.2%) (P <0.01); The VEGF-C expression did not show any correlation with sex, age, and tumour size (r=0.008，0.025，0.013,P> 0.05), but show significant correlation with TNM stages (r=0.447,P<0.01), as the TNM stages increasing, the VEGF-C positive expression is significantly higher.［Conclusions］Colon cancer could express VEGF-C, and influence lymphatic metastasis in colon cancer. The present results suggested that the patients with increased expression of VEGF-C without lymphatic metastasis have strong tendency of lymphatic metastasis.