芪参降脂饮抗动脉粥样硬化机制的实验研究

Mechanism of action of Qishenjiangzhiyin(QSJZY) on experimental atherosclerosis rats

关键词:  芪参降脂饮  动脉粥样硬化  胰岛素抵抗

Key words:  Qishenjiangzhiyin(QSJZY)  atherosclerosis  insulin resistance

摘要:

［目的］探讨芪参降脂饮抗动脉粥样硬化(atherosclerosis,AS)的作用机制。［方法］40只大鼠随机分为4组，正常对照组、高脂对照组、不同浓度芪参降脂饮组2组。通过测血脂谱、血FPG、FINS，并计算胰岛素敏感指数（insulin sensitivity index, ISI），分析芪参降脂饮降低血脂，改善胰岛素抵抗(insulin〖KG*2〗resistance，IR)进而起到抗AS的作用。［结果］芪参降脂饮大剂量治疗组大鼠TC(3.36±0.28 ) mmol/L、LDL-C(1.24±0.31 ) mmol/L、FPG(8.65±0.78 ) mmol/L、FINS(12.01±1.09 ) mmol/L显著低于高脂对照组，而HDL-C(0.97±0.41) mmol/L、ISI(-4.53±0.08)明显升高( P< 0.01)。小剂量治疗组与高脂对照组比较无明显差异( P> 0.05 )。［结论］芪参降脂饮可以降低血脂，改善胰岛素抵抗,进而起到抗AS的作用,且治疗效果与剂量有关。

Abstract:

［Objective］To study the mechanism of action of Qishenjiangzhiyin(QSJZY) on experimental atherosclerosis(AS) rats induced by high fat diet.［Methods］ Forty rats were randomized into four groups：normal control group, high-fat model group , two different dose Qishenjiangzhiyin (QSJZY) groups. Serum lipids, FPG, FINS, were measured and ISI was calculated after experiment. The mechanisms of QSJZY’s antiatherosclerosis action were deduced. ［Results］In high dose treatment group, TC(3.36±0.28 )mmol/L、LDL-C (1.24±0.31) mmol/L、FPG(8.65±0.78 ) mmol/L and FINS(12.01±1.09 )mmol/L were significantly lower while HDL-C(0.97±0.41)mmol/L、ISI(-4.53±0.08) were significantly higher than those in high-fat model group(P<0.01).No significant difference existed between low dose treatment group and high-fat model group.［Conclusions］QSJZY can decrease serum lipids and enhance IS and weaken IR, which might be the mechanisms of QSJZY's antiatherosclerosis action . And QSJZY's treatment effect is correlated to it's dose.