| 摘要: |
| ［目的］为使用他克莫司的肝移植患者制定有效的治疗窗浓度。［方法］用酶联免疫法测定全血他克莫司谷浓度，并对他克莫司谷浓度的监测结果进行回顾性分析。［结果］ 他克莫司治疗窗浓度范围为：第1个月内为10～17 ng/mL，第2～3个月为9～11 ng/mL，4～12个月为5～8 ng/mL。［结论］此浓度既能达到满意的免疫抑制效果，又能减少他克莫司的不良反应。 |
| 关键词: 他克莫司 血药浓度 酶联免疫法 肝移植 |
| DOI：10.11724/jdmu.2006.05.25 |
| 分类号:R927 |
| 基金项目: |
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| Determination of concentration of tacrolimus of liver transplant recipients in whole blood with ELISA |
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ZHANG Ning1, LV Huiyi1, FAN Guangjun1, DENG Sa2
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1.The Second Affiliated Hospital of Dalian Medical University， Dalian 116027， China;2.Dalian Medical University，Dalian 116027, China
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| Abstract: |
| ［Objective］To find out the valid window concentration of tacrolimus in Chinese liver transplant recipients. ［Methods］ The whole blood concentrations of tacrolimus were measured by ELISA. The levels of tacrolimus in samples were compared and studied.［Results］ The blood FK506 trough level was 10～17 ng/mL within the first month,9～11 ng/mL from the second to third month,5～8 ng/mL from the fourth to the twelvth month.［Conclustons］ This range of therapeutic window concentration of FK506 trough levels is ideal for Chinese liver transplant recipients with less rejection and toxic effects. |
| Key words: FK506 blood concentration ELISA liver transplantation |
