| 摘要: |
| 瘦素是由脂肪组织分泌的肥胖基因编码的产物;它必须通过与位于下丘脑核区的瘦素受体结合,方能发挥调节机体能量代谢等作用.同时,瘦素受体与瘦素在外周与中枢间的交流中也有重要作用.因此,瘦素受体的研究越来越成为热点.对瘦素受体的基因结构、拼接异构体、分布及功能、信号传导及与其他激素特别是胰岛素之间关系的研究进展作了概要综述. |
| 关键词: 瘦素 瘦素受体 糖尿病 |
| DOI：10.11724/jdmu.2004.02.27 |
| 分类号:Q7 |
| 基金项目: |
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| Progress of ob gene receptor molecular biological investigation |
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WU Nan, TAN Huan-ran
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Department of Pharmacology, School of Basic Medicine, Peking University Health Science Center, Beijing University, Beijing 100083,China
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| Abstract: |
| The adipocyte-derived hormone leptin mediates the energy balance by binding its receptor in hypothalamic nuclei. Leptin and leptin receptor play an important role in the communication between central and peripheral systems. The paper aimed to review the new progress of investigation into Ob-R gene structure, spliced isoform, distribution, function and signal transfer. At the mean time, we analyzed the relationship between leptin receptor and other hormones, especially the relationship between Ob-R and insulin. |
| Key words: leptin Ob-R diabetes |