引用本文:杨静娴,林原.原肌球蛋白的分子生物学研究进展[J].大连医科大学学报,2004,26(2):.
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原肌球蛋白的分子生物学研究进展
杨静娴, 林原
大连医科大学,药理学教研室,辽宁,大连,116027
摘要:
原肌球蛋白(TM)是肌肉收缩过程中重要的调节蛋白质,它以大量异构体形式广泛分布于各种真核细胞中.哺乳动物中的4个TM基因已被确认,分别命名为TPM1、TPM2、TPM3、TPM4,至少可表达出20种TM异构体.TPM1基因突变与家族性肥大性心肌病有关;TPM3基因突变与线状肌病和骨骼肌无力有关.
关键词:  原肌球蛋白  基因突变  异构体  肌病
DOI:10.11724/jdmu.2004.02.26
分类号:Q7
基金项目:
Advances in molecular biological research on tropomyosin
YANG Jing-xian, LIN Yuan
Department of Pharmacology, Dalian Medical University, Dalian 116027, China
Abstract:
Tropomyosin(TM)was one of the most important regulating pro teins of the muscle contractile system. It was widely distributed in eucaryote cells in a large number of isoforms. So far four TM genes had been identified in mammals ,from which at least 20 isoforms were expressed. The four genes have been named TPM1,TPM2,TPM3 and TPM4. Mutations in TPM1 gene are associated with familia l hypertrophic cardiomyopathy and the mutation in TPM3 gene is associated with nemaline myopathy and weakness of skeletal muscle.
Key words:  tropomyosin  genic mutation  isoform  myopathy