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| 肾多巴胺受体阻断对脑室高张盐溶液注射引起促钠排泄作用的影响 |
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傅雷1, 林茂樟2, 姜春玲2, 娄礼广3
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1.大连医科大学,机能室,辽宁,大连,116027;2.大连医科大学,生理学教研室,辽宁,大连,116027;3.大连市中心医院,普外科,辽宁,大连,116033
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| 摘要: |
| 观察阻断麻醉家兔肾多巴胺受体后脑室高张盐溶液注射引起的促钠排泄和利尿反应的作用。[方法]侧脑室注射高张盐溶液或人工脑脊液，观察动物排钠量、排钾量、尿量和血压的变化。［结果］单纯高张盐溶液组和氟派啶醇预处理组在侧脑室注射高张盐溶液后开始后1～30 min内排钠量、尿量均显著增加（P＜0.05）；两组的排钠量、尿量均达到蜂值（11～20 min）的排钠量、尿量分别为（35.2±5.8）、（6.2±13.5）μmol/min（P＞0.05）；尿量分别为（386.6±112.4）、（338.6±116.7）μL/min（P＞0.05）。［结论］与单纯高张盐溶液组比较，肾多巴胺受体阻断后家兔侧脑室注射高张盐溶液后可明显引起促钠排泄和尿量增加的作用无明显改变 |
| 关键词: 促钠排泄 肾多巴胺受体 高张盐溶液 |
| DOI：10.11724/jdmu.2003.02.05 |
| 分类号:R33 |
| 基金项目: |
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| Influence of renal dopamine receptor blockade on natriuresis induced by intracerebrovetricular injection of hypertonic saline in rabbits |
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FU Lei1, LIN Mao-zhang2, JIANG Chun-ling22, LOU Li-guang33
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1.Department of Functional Lab,Dalian Medical University, Dalian 116027 ,China;2.Department of Physiology ,Dalian Medical University, Dalian 116027 ,China;3.Department of General Surgery,Centre Hospital of Dalian,Dalian 116030,China)
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| Abstract: |
| To observe the effects of renal dopamine receptor blockade on natriuresis induced by intracerebrovetricular injection of hypertonic saline in anesthetized rabbits.［Methods］ Injected hypertonic saline or artifial cerebrospinal fluid intracerebroventricular,observed animal's urinary sodium excretion (UNaV), urinary potassium exretion (UKV), urinary volume (UV), and mean arterial pressure (MAP). ［Results］ UNaV, UV increased remarkably after injection of hype rtonic saline 11～20 min in ctrl group and hal+ctrl group (P<0.05); the peak of U NaV were 35.2±5.8and 46.2±13.5 μmol/min in the two groups respectively ( P>0.05); the peak of UV were （386.6±112.4） and （338.6±116.7）μ/min respectively (P>0.05). ［Conclusion］ These results indicate that injection of hypertonic saline in anesthelized rebbits may set off a reaction of natriuresis; these reaction in two the groups have no difference obviously |
| Key words: natriuresis renal dopamine receptor hypertonic saline |