| 摘要: |
| 目的:研究具有钙拮抗作用的中药蝙蝠葛碱对多耐药性的逆转作用.方法:选用异搏定作阳性对照,观察其对多药耐药细胞株K562/ADM多药耐药性的逆转作用.结果:蝙蝠葛碱在非细胞毒性剂量下能使K562/ADM对阿霉素的浓度升高,但对细胞表面的糖蛋白P-170却没有影响.结论:蝙蝠葛碱具有逆转白血病细胞株K562/ADM多药耐药性的作用. |
| 关键词: 蝙蝠葛碱 多药耐药性 K562/ADM 逆转 |
| DOI：10.11724/jdmu.2002.02.05 |
| 分类号:R73-3 |
| 基金项目: |
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| Reversal of multidrug resistance in human K562/ADM cell line by dauricine |
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LI Jian-hua1, QIN Feng-qi2, YANG Pei-man3
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1.. The Third Affiliated Hospital of Dalian Medical University，Dalian 116600，China;2.the First Affiliated Hospital of Dalian Medical University,116011;3.Department of History and Embriology, Dalian Medical University， Dalian 116023)
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| Abstract: |
| To find effective herb medicine having the potency of reversing multidrug resistance (MDR) Method:Dauricine, one kind of herd medicine,has been selected to study its reversal effect to K562/ADM cell line comparing with verapamil as positive control. Results:Dauricine can reduce the value of IC50 of adrimycin and incristine against MDR cell line K562/ADM at non-cytotoxic concentration and enhance accumulation of adriamycin and daunorubicin, but cause no change in the expression of P-170.Conclusion:Dauricine can reverse MDR of K562/ADM to some extent |
| Key words: dauricine reverse multidrug-resistance |