| 摘要: |
| 目的:探讨衰变加速因子(CD55)、反应性溶血膜抑制物(CD59)在阵发性睡眠性血红蛋白尿(PNH)诊断中的意义.方法:用流式细胞仪检测CD55、CD59的表达量(%).结果:PNH组CD55、CD59明显低于AA-PNH组和AA组、对照组.结论:检测患者外周血粒细胞膜表面抗原CD55、CD59可作为PNH的早期确诊指标,其中CD59是较敏感指标,CD55是特异性指标. |
| 关键词: CD55 CD59 阵发性睡眠性血红蛋白尿(PNH) |
| DOI：10.11724/jdmu.2001.04.18 |
| 分类号:R446.1 |
| 基金项目: |
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| The significance of CD55 and CD59 for diagnosing paroxysmal nocturnal hemoglobinuria (PNH) |
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LI Rui-hua, HE Xiao-lin, WANG Wei-dong
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Department of Clinical Laboratory, the Second Affiliated Hospital, Dalian Medical University, Dalian 116027,China)
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| Abstract: |
| To study the significance of Decay Accelerating Factor(DAF=CD55)、Membrane Inhibitor of reactive Lysis (MIRL=CD59) in the diagnostic of paroxysmal nocturnal hemoglobinuria (PNH). Methods: Flow cytometric analysis of CD55、CD59 was carried to detect the deficiency of membrane protein to the cell surface. Results: The level of CD55(45.94±6.06)%, CD59(46.40±12.36)% of PNH group was significantly lower than that of in AA-PNH CD55(71.00±0.43)%，CD59(84.62±2.08)%, in AA CD55(99.19±0.86)%, CD59(94.42±2.92)% and control group CD55(99.23±0.95)%, CD59(98.56±1.25)%. Conclusion: CD55 and CD59 is a useful target to diagnose and characterize PNH. |
| Key words: CD55 CD59 paroxysmal nocturnal hemoglobinuria(PNH) |