| 摘要: |
| 探讨尿蛋白定性阴性的糖尿病肾病(DN)患者随机尿中三种微量蛋白检测对发现糖尿病早期肾损害的意义。方法：尿微量白蛋白(MA)、α1-微球蛋白(α1-MG)和转铁蛋白(TRF)用速率散射比浊法，尿肌酐（Cr）采用Jaffe比色法进行测定。结果：尿蛋白定性阴性的DN组尿MA/Cr为（3.410±2.366）mg/mmol，TRF/Cr为(0.342±0.272) mg/mmol,α1-MG/Cr为(3.206±2.751) mg/mmol, 对照组MA/C为(0.713±0.126)mg/mmol, TRF/Cr为(0.137±0.084) mg/mmol,α1-MG/Cr为(0.915±0.366) mg/mmol。两组比较具有极显著性差异（P＜0.01)。结论：尿MA、TRF及α1-MG可作为发现糖尿病早期肾损害敏感而又可靠的常规指标 |
| 关键词: 糖尿病肾病 微量白蛋白 转铁蛋白 α1-微球蛋白 肌酐 |
| DOI：10.11724/jdmu.2001.04.19 |
| 分类号:R446.1 |
| 基金项目: |
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| Clinical applications of the uromicroprotein in early renal injuries |
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CHEN Zhen, CAO Hua-jun
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Department of Clinical Laboratory, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China)
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| Abstract: |
| To discover early renal disease of diabetes mellitus (DM) by determining three microproteins in random urine. Methods: Urinemicroproteins were detected by the method of immunoturbidimetry. Urinary creatinine was measured using colorimetry. Results: The levels of urinary MA/Cr, TRF/Cr and α1-MG/Cr in urinary albumin negative group were （3.410±2.366）mg/mmol, (0.342±0.272) mg/mmol, (3.206±2.751) mg/mmol respectively.The levels in the controls were (0.713±0.126) mg/mmol, (0.137±0.084) mg/mmol, and(0.915±0.366) mg/mmol respectively. There was marked difference between two groups (P＜0.01).Conclusions: The urinary MA/Cr, TRF/Cr and α1-MG/Cr can be used as sensitive and reliable indexes for early renal disease of DM |
| Key words: diabetic nephropathy microalbumin transferin α |