| 摘要: |
| HCa-F和HCa-P是同源且转移能力不同的肝癌细胞系,P为低转移(转移率＜30%),F为高转移(转移率＞80%).经Sp法免疫组化染色发现:FasL在F原发瘤中的表达显著强于P原发瘤(P＜0.01),Bcl-2在两者均为强阳性,无显著性差别.提示FasL可能赋予F细胞杀伤免疫细胞的能力并与其较强的转移力相关. |
| 关键词: 转移 FasL Bcl-2 |
| DOI：10.11724/jdmu.2000.01.05 |
| 分类号:Q786 R73 |
| 基金项目: |
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| The expression of FasL and Bcl- 2 in mouse hepatocarcinoma |
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Wang Huailian1, Hou Li2, Ling Mao Ying2
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1.The Fourth Hospital of Dalian,Dalian,China;2.Department of Pathology,Dalian Medical University,Dalian,China
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| Abstract: |
| HCa-F(F) and HCa-P(P) are mouse hepatocarcinoma cell lines with different metastatic potential.F cells had high metastatic ability.FasL and Bcl-2 expressions were detected in F and P cells immunohistochemically.F cells expressed FasL much greater than P cells.Both of F and P cells expressed Bcl-2 strongly and equally.This result suggested that expression of FasL may be related to their metastatic ability |
| Key words: metastasis FasL Bcl-2 |