| 摘要: |
| 乳糜泻（celiac disease，CD）又称麦胶敏感性肠病，是一种在遗传易感个体中由麦胶诱导的自身免疫性肠道疾病。除麦胶之外，消化道菌群紊乱可能是诱发CD的另一环境因素，而麦胶代谢与消化道菌群有着密切联系。本文从麦胶生物学特性、麦胶与消化道菌群的相互关系、无麦胶饮食对消化道微生物的影响、益生菌对CD的影响4个方面，综述乳糜泻中麦胶与消化道菌群相关性研究进展，探讨微生态制剂辅助治疗乳糜泻的前景及其潜在机制。 |
| 关键词: 麦胶 消化道菌群 乳糜泻 无麦胶饮食 益生菌 |
| DOI：10.11724/jdmu.2021.03.12 |
| 分类号:R574.51 |
| 基金项目:国家自然科学基金项目（81873160） |
|
| Research progress on the relationship between gluten and gastrointestinal microbiome in celiac disease |
|
WU Xingxing1, WU Jing2, SHAN Zhaowei1
|
|
1.Department of Gastroenterology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China;2.Chinese Medicine Institute of Nanjing University, Nanjing Drum Tower Hospital, Drum Tower Clinical Medicine College of Nanjing University of Chinese Medicine, Nanjing 210008, China
|
| Abstract: |
| Celiac disease(CD), also known as gluten sensitive enteropathy, is an autoimmune intestinal disease induced by gluten in genetically susceptible individuals. Other than gluten, gastrointestinal tract flora dysbiosis is another environmental factor inducing celiac disease. Gluten metabolism is closely related to gastrointestinal tract microbiota. We reviewed the relationship between gluten and gastrointestinal microbiome in celiac disease on four aspects including biological medication of gluten, relationship between gluten and gut microflora, effect of gluten free diet on microbes, and effect of probiotics on CD, as well as the prospective and potential mechanism of microecological agents in treating CD. |
| Key words: gluten gastrointestinal microbiome celiac disease gluten free diet probiotics |
