趋化因子CXCL12在中枢神经系统疾病中作用的研究进展

Advances in research on chemokine CXCL12 and central nervous system diseases

关键词:  CXCL12  CXCR4  ACKR3  中枢神经系统

Key words:  CXCL12  CXCR4  ACKR3  central nervous system

摘要:

CXCL12属于CXC趋化因子家族，与其特异性受体CXCR4和ACKR3相互作用，构成CXCL12/CXCR4/ACKR3反应轴，参与多种生理和病理过程，如参与胚胎发生、造血和血管生成，影响肿瘤的生长、转移和侵袭，促进人类免疫缺陷病毒和肿瘤病毒的感染，延缓类风湿性关节炎的病情发展，促进骨关节炎患者的骨重塑等。近年来研究发现，CXCL12在中枢神经系统发育中发挥着必不可少的作用，且与肌萎缩侧索硬化症、阿尔茨海默病和多发性硬化症等疾病密切相关。本文将对CXCL12/CXCR4/ACKR3反应轴的生理学功能及在中枢神经系统疾病中的作用作一综述。

Abstract:

CXCL12 belongs to the CXC chemokine family, interacts with its specific receptors CXCR4 and ACKR3 to form the CXCL12/CXCR4/ACKR3 reaction axis and participates in a variety of physiological and pathological processes, such as physiology involved in embryogenesis, hematopoiesis and angiogenesis. It affects tumor growth, metastasis and invasion, assists in the infection of human immunodeficiency virus and tumor-associated virus, delays the development of rheumatoid arthritis, and promotes bone remodeling in patients with osteoarthritis. In recent years, many studies have found that CXCL12 plays an essential role in the development of the central nervous system and is closely related to diseases such as amyotrophic lateral sclerosis, Alzheimer's disease and multiple sclerosis. This article reviews the physiological functions of the CXCL12/CXCR4/ACKR3 reaction axis and its role in central nervous system diseases.