惊恐障碍的临床研究进展

Research progress on panic disorder

关键词:  惊恐障碍  惊恐发作  神经生物学  事件相关脑电位  临床表现  药物治疗

Key words:  panic disorder  panic attack  neurobiology  event-related brain potentials  clinical manifestation  drug therapy

摘要:

惊恐障碍（panic disorder, PD）是一种慢性焦虑，其核心特征是反复发生非预期惊恐发作（Panic attack,PA），而后者特征在于突然，强烈的恐惧/不适发作，伴有胸痛，心悸，呼吸困难和呼吸困难等躯体症状。患者还表现出预期焦虑和/或与PA有关的行为不适应性变化。PD是多系统表现的常见病，与多种疾病共病。治疗可以选择药物治疗和非药物治疗。积极控制PD需要充分了解心理治疗和药物治疗的有效性和副作用。

Abstract:

Panic disorder (PD) is a chronic anxiety disorder, and its core features are recurrent, unexpected panic attacks (PAs) characterized by sudden, intense fear/discomfort episodes, accompanied by a surge of somatic symptoms such as dyspnea, palpitations, chest pain, and breathlessness. There are anticipatory anxiety and/or maladaptive changes in the patient’s behavior related to PAs. PD is common in clinical practice with multiple system symptoms, and frequently comorbid with other psychiatric and medical conditions. Treatment can be selected with pharmacological and psychological therapy. A good understanding of the efficacy and side effect profiles of different treatments is required by optimal management.