| 摘要: |
| 内源性非编码小分子miRNA-223可作用于靶基因调控肝癌的发生发展，对肝癌细胞增殖、迁移、侵袭、凋亡以及耐药等生物学功能产生影响。血清与肿瘤中miRNA-223的表达水平对肝癌的诊断与治疗具有一定的参考价值，是肝癌诊断、治疗以及判断预后潜在的生物标志物。本文对近年来miRNA-223在肝癌中的研究进展作一综述。 |
| 关键词: 肝癌 miRNA-223 IGF-IR STMN1 NLRP3 整合素αV亚基 |
| DOI：10.11724/jdmu.2019.03.17 |
| 分类号:R735.7 |
| 基金项目: |
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| Research advance of miRNA-223 in hepatocellular carcinoma |
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ZHANG Lei1, GONG Zezhong1, LI Yan2
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1.The Second Clinical College，Dalian Medical University，Dalian 116044，China;2.Department of Anatomy，Dalian Medical University，Dalian 116044，China
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| Abstract: |
| MiRNA-223 is a kind of endogenous small non-coding RNA, which has been shown to regulate the progression of hepatocellular carcinoma by targeting tumor suppressor or oncogenes. It plays a key role in cell proliferation, migration, invasion and drug resistance of hepatocellular carcinoma cell. The expression level of miRNA-223 in serum and liver tissues provides important reference value for the diagnosis and treatment of hepatocellular carcinoma, which makes miRNA-223 a potential biomarker for diagnosis, treatment and prognosis of hepatocellular carcinoma in clinic. We reviewed the research progress of microRNA223 in hepatocellular carcinoma in recent years. |
| Key words: hepatocellular carcinoma miRNA-223 IGF-IR STMN1 NLRP3 integrin αV |
