辛芩颗粒与氯雷他定联合用药对变应性鼻炎患者IFN-γ、IL-4、血清甲壳质酶蛋白-40的影响

Effects of combined treatment of Xinqin particles and loratadine tablets on serum IFN-γ，IL-4 and YKL-40 levels in patients with allergic rhinitis

关键词:  变应性鼻炎  辛芩颗粒  氯雷他定  IFN-γ  IL-4  YKL-40

Key words:  allergic rhinitis  Xinqin particles  loratadine tablets  IFN-γ  IL-4  YLK-40

摘要:

目的　探讨辛芩颗粒与氯雷他定联合用药对变应性鼻炎患者血清中干扰素-γ（IFN-γ）、白细胞介素-4（IL-4）和血清甲壳质酶蛋白-40（YKL-40）含量的影响。方法　选择2015年5月至2016年5月就诊的124例变应性鼻炎患者为研究对象，随机分为观察组和对照组，每组62人。对照组采用氯雷他定治疗，观察组加用辛芩颗粒联合治疗。对比两组患者临床疗效及治疗前后血清中IFN-γ、IL-4和YKL-40水平变化情况。结果　治疗后，观察组的临床总有效率（95.2%）显著高于对照组(77.4%)，差异有统计学意义（P<0.05）；与治疗前比较，治疗后两组血清中IFN-γ浓度水平均上升，IL-4和YKL-40浓度水平均下降，差异均有统计学意义（P<0.05）；治疗后观察组IFN-γ浓度水平高于对照组，IL-4和YKL-40浓度水平低于对照组，组间差异均具统计学意义 （P<0.05）。观察组和对照组不良反应的发生率分别为1.61%和3.23%，差异无统计学意义（P＞0.05）。结论　联用辛芩颗粒和氯雷他定治疗变应性鼻炎能够显著提高临床疗效，缓解病情，且安全可靠。

Abstract:

Objective To explore the effects of combined treatment of Xinqin particles and loratadine tablets on change of serum IFN-γ, IL-4 and YKL-40 levels in patients with allergic rhinitis. Methods Totally 124 allergic rhinitis patients, who were treated in the hospital from May 2015 to May 2016, were enrolled in the study. The patients were divided into observation group and control group randomly with 62 patients in each group. The patients in control group were treated with loratadine tablets and the patients in observation group were treated with combined treatment of Xinqin particles and loratadine tablets. Serum levels of IFN-γ, IL-4 and YLK-40 in both groups were measured. Results The overall clinical effective rate was significantly higher in observation group (95.2%) compared to control group (77.4%) after treatment (P<0.05). In both groups, serum IFN-γ levels were higher after treatment than those before treatment, and IL-4 and YLK-40 levels lower than those before treatment, the differences were statistically significant (P<0.05). After treatment, serum IFN-γ level in observation group was higher than that in control group, and IL-4 and YLK-40 levels lower than those in control group, the differences were statistically significant (P<0.05). The rates of adverse reactions in observation group and control group were 1.61% and 3.23%, respectively. There was no statistically significant difference between the two groups (P>0.05). Conclusion Combined treatment of Xinqin particles and loratadine tablets can effectively improve clinical efficacy and relieve the symptoms of allergic rhinitis. The treatment is safe and reliable.