肌球蛋白轻链激酶与炎症性疾病关系的研究进展

Research progress of myosin light chain kinase and inflammatory disease

关键词:  肌球蛋白轻链激酶  炎症  屏障功能

Key words:  myosin light chain kinase  inflammation  barrier function

摘要:

肌球蛋白轻链激酶（myosin light chain kinase，MLCK）可以调控肌球蛋白轻链的磷酸化，进而调控基于肌动蛋白与肌球蛋白之间相互作用的细胞骨架活动。近几年研究报道，长链MLCK与短链MLCK的异常表达在不同的炎症性疾病中多有发生，炎症相关因子能诱导MLCK表达升高。本文对MLCK在肺炎、血管损伤以及炎性肠病中的作用，及MLCK参与炎症性疾病的可能信号通路进行了综述。

Abstract:

Myosin light chain kinase (MLCK) regulates cytoskeletal activity in response to myosin light chain phosphorylation, which is also based on the interaction between actins and myosin. Recent studies have shown that abnormal expression of long-chain MLCK and short-chain MLCK is involved in different inflammatory diseases and inflammation-related factors induces MLCK expression. This review summarizes the role of MLCK in the pathogenesis of pneumonia, vascular injury and inflammatory bowel disease, and summarizes the possible signaling pathways involved in inflammatory diseases, suggesting that MLCK has a potential role in the treatment of inflammatory diseases.