绝经后子宫内膜样腺癌患者临床病理因素与复发的关系研究

Association between recurrence and clinical pathological features among women with endometrioid endometrial cancer after menopause

关键词:  子宫内膜样腺癌  绝经  复发

Key words:  endometrioid endometrial cancer  postmenopause  recurrence

摘要:

目的　探讨绝经后子宫内膜样腺癌患者临床病理因素与复发的相关性。方法　收集术后病理证实为子宫内膜样腺癌的201例绝经后患者的临床病理资料和随访情况。χ²检验或Fisher精确检验和logistic回归分析患者复发与组织学分级、侵肌深度、淋巴结受累、宫颈间质受累及淋巴血管间隙浸润（LVSI）的关系。结果　单因素分析显示子宫内膜样腺癌患者侵肌深度、淋巴结受累及淋巴血管间隙浸润在复发组与未复发组间差异有显著性意义（P<0.05）；Logistic回归分析侵肌深度和淋巴结受累与复发相关（P<0.05）。结论　绝经后子宫内膜样腺癌患者，病理资料示侵肌深度≥1/2及有淋巴结受累，将增加患者复发风险。

Abstract:

Objective 　To investigate the association between recurrence and clinical pathological features among women with endometrioid endometrial cancer after menopause.　Methods 　 Data from postmenopausal patients with endometrioid endometrial cancer were retrospectively analyzed. Associations between recurrence and tumor grade, myometrial invasion, lymph node status, lymphovascular space invasion(LVSI), cervical-stromal invasion were assessed by student t tests, chi-squaretests, fisher exact text and logistic regression analysis.　Results 　 In the univariate analysis, myometrial invasion, lymph node involvement and LVSI were significantly different betweenpatients with recurrence and without recurrence(P<0.05). Logistic regression analysis showed that deep myometrial invasion and lymph node involvement had an independent association with recurrence (P<0.05).　Conclusion 　Inpatients with endometrioid endometrial cancer after menopause,the risk of recurrence would increase if the patients have myometrial invasion ≥50% and positive lymph node involvement.