miRNA与大肠癌关系的研究进展

Research progress on miRNA and colorectal cancer

关键词:  大肠癌  miRNA  生物标记物  预后

Key words:  [Key words]　colorectal cancer  miRNA  biomarker  prognosis

摘要:

[摘要]　大肠癌是消化系统常见的恶性肿瘤，早期诊断、早期治疗可以改善预后。微小RNAs (microRNAs或miRNAs)是一类单链非编码的 RNA调控因子，可作为肿瘤抑制基因或癌基因而调控肿瘤的发生、发展。近年来，随着对miRNA作用机制及其与肿瘤关系研究的深入，越来越多的证据表明，miRNA在大肠癌的表达、发生、转移、诊断、治疗、预后等方面均发挥着重要的作用。本文就近年来有关miRNA与大肠癌的关系研究进展进行综述。

Abstract:

[Abstract]　Colorectal cancer is one of the most common malignant gastrointestinal tumors. Early diagnosis and prompt treatment can help to achieve a favorable prognosis. MicroRNA/miRNA, a single-strand noncoding-RNA family, functions as an oncogenes or tumor suppressor genes, regulating the genesis and development of tumors. Nowadays, a great amount of studies have been conducted on the mechanisms of microRNAs and their relationship with neoplasm. Accumulating evidences indicate that miRNAs play a vital role in tumor genesis and metastasis and serve as markers of diagnosis, treatment and prognosis of colorectal carcinoma. This article reviews recent studies on the relationship between miRNA and colorectal cancer.