| 摘要: |
| [摘要] 窖蛋白1（caveolin-1）是胞膜窖（caveolae）上的标志性蛋白，能够识别多种信号分子，与肿瘤的侵袭转移及血管生成等过程密切相关。而caveolin-1在肿瘤血管生成中的作用尚未定论，目前认为caveolin-1在肿瘤及其血管生成中具有促进及抑制双重作用。随着研究的不断深入，caveolin-1很可能成为肿瘤的治疗靶点或早期诊断指标。本文就caveolin-1在肿瘤及其血管生成的作用进行综述。 |
| 关键词: 窖蛋白1 肿瘤 血管生成 |
| DOI：10.11724/jdmu.2015.03.22 |
| 分类号: |
| 基金项目:基金项目：国家自然科学基金项目（81271910）；辽宁省百千万人才资助项目(2012921014) |
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| Role of caveolin-1 in tumor and tumor angiogenesis |
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SUN Yuan, ZHOU Hui-min
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Department of Microbiology, Dalian Medical University, Dalian 116044, China
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| Abstract: |
| [Abstract] Caveolin-1，the marker protein of caveolae, could recognize a variety of signal molecules and might be related to tumor metastasis and angiogenesis. The role of caveolin-1 in tumor angiogenesis has not been ascertained yet. It has been shown that caveolin-1 might play a dual function in tumor angiogenesis: either promoting or inhibiting. Caveolin-1 might act as an early diagnostic marker and therapeutic target in carcinoma. This article will review the effects of caveolin-1 on tumor invasion and angiogenesis and discuss the underlying mechanisms. |
| Key words: [Key words] caveolin-1 carcinoma angiogenesis |
