| 摘要: |
| [摘要] miRNA是一类内源性非编码的小RNA，它可以通过降解或抑制靶mRNA参与基因表达的调控。miRNA在心血管的生理病理改变中起着重要的作用。miRNA-29家族是其中之一，它既参与维持主动脉血管的完整性，又参与了动脉粥样硬化的调节，它还在心肌纤维化过程中发挥作用等。这些研究可以为临床诊治提供基因水平的诊断依据和新的治疗方向。 |
| 关键词: 微小RNA 微小RNA-29 心血管疾病 |
| DOI：10.11724/jdmu.2014.06.21 |
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| 基金项目: |
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| Role of microRNA-29 in progression of cardiovascular diseases |
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YANG Fan 1, KANG Jian 2, MA Yu-fang 31,2
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1.Seven-year Program of Clinical Medicine, Dalian Medical University，Dalian 116044，China;2.Department of Biochemistry, Dalian Medical University，Dalian 116044, China
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| Abstract: |
| [Abstract] microRNAs (miRNAs) are a class of endogenously expressed small non-coding RNAs. They participate in the regulation of gene expression by means of degradating or silencing mRNAs. miRNAs play important roles in the physiological and pathological changes of cardiovascular disease. miRNA-29, one of the miRNA family, takes part in maintaining the integrity of aorta, is involved in the regulation of atherosclerosis, and also plays a role in the process of myocardial fibrosis. These studies will provide the basis for clinical diagnosis at gene level and new treatment strategy. |
| Key words: [Key words] miRNA miRNA-29 angiocardiopathy |
